Department of Biochemistry, McGill University, Montreal, Quebec, Canada.
Trends Cell Biol. 2012 May;22(5):231-40. doi: 10.1016/j.tcb.2012.02.002. Epub 2012 Mar 5.
The transport and sorting of cell surface receptors into membrane-bound intracellular compartments is crucial for cellular homeostasis. Defects in receptor trafficking are associated with several diseases, including cancer. Recent advances in our understanding of mechanisms that control receptor trafficking have highlighted the involvement of membrane trafficking in cell signaling, as well as in biological processes, including cell migration and invasion. In this review, we summarize current knowledge of how cargos, focusing on receptor tyrosine kinases (RTKs) and integrins, are dynamically transported through the endosomal pathway for recycling, and how this promotes spatially restricted signaling microdomains associated with distinct biological responses. We discuss mechanisms through which dysregulation of membrane trafficking contributes to tumorigenesis and potential therapeutic approaches.
细胞表面受体的运输和分拣到膜结合的细胞内隔室对于细胞内稳态至关重要。受体运输缺陷与包括癌症在内的几种疾病有关。最近我们对控制受体运输的机制的理解的进展突出了膜运输在细胞信号转导以及包括细胞迁移和侵袭在内的生物学过程中的参与。在这篇综述中，我们总结了目前关于货物（重点是受体酪氨酸激酶（RTKs）和整合素）如何通过内体途径动态运输进行回收的知识，以及这如何促进与不同生物学反应相关的空间受限信号微区。我们讨论了膜运输失调如何导致肿瘤发生的机制以及潜在的治疗方法。
