Centro per la Prevenzione e Cura del Tabagismo, Azienda Ospedaliero-Universitaria Policlinico-V. Emanuele, Università di Catania, Catania, Italy.
Curr Opin Pharmacol. 2012 Jun;12(3):229-37. doi: 10.1016/j.coph.2012.02.005. Epub 2012 Mar 5.
Smoking is the leading cause of premature mortality in western countries and it is important for smokers to stop as early as possible. Several approaches for cessation are available but they lack high levels of efficacy. Consequently, there is a compelling need for more effective approaches and safer medications to aid smokers in achieving long-term abstinence. Expanding knowledge in our understanding of the mechanisms involved in tobacco dependence is leading to the development of novel therapies and vaccines for smoking cessation, many of which are currently in the advanced stage of development and offer promise. Here we will review efficacy and safety data from human clinical trials of current and emerging therapies and tools which are approved or undergoing investigation.
吸烟是导致西方国家过早死亡的主要原因，因此吸烟者尽早戒烟非常重要。有几种戒烟方法可供选择，但它们的效果都不是很高。因此，迫切需要更有效的方法和更安全的药物来帮助吸烟者实现长期戒烟。对烟草依赖相关机制的深入了解，促进了新型戒烟疗法和疫苗的研发，其中许多疗法和疫苗已经进入开发的后期阶段，前景可期。在这里，我们将回顾目前已批准或正在研究的新型疗法和工具的人体临床试验的疗效和安全性数据。
