Russo Cristina, Cibella Fabio, Caponnetto Pasquale, Campagna Davide, Maglia Marilena, Frazzetto Evelise, Mondati Enrico, Caruso Massimo, Polosa Riccardo
Centro per la Prevenzione e Cura del Tabagismo, Azienda Ospedaliero-Universitaria "Policlinico-V. Emanuele", Università di Catania, Catania, Italy.
Institute of Internal Medicine, S. Marta Hospital, Azienda Ospedaliero-Universitaria "Policlinico-V. Emanuele", Università di Catania, Catania, Italy.
Sci Rep. 2016 Jan 5;6:18763. doi: 10.1038/srep18763.
Stop smoking it is often associated to weight gain that is one of the most important causes for relapse. This is the first study to describe long-term changes in body weight in smokers invited to quit or reduce smoking by switching to ECs. Conventional cigarettes consumption and body weight were measured prospectively in a randomized controlled trial of smokers invited to switch to ECs. Post cessation weight changes from baseline at week-12, -24 and -52 were compared among 1) high, medium and zero nicotine strength products and 2) pooled continuous smoking failure, smoking reduction and abstinence phenotypes. Saliva cotinine levels and appetite levels were also measured. No significant changes in body weight were observed among high, medium and zero nicotine strength products. Differences among continuous smoking phenotypes were significant only at week-12 (p = 0.010) and week-24 (p = 0.012) with quitters gaining 2.4{plus minus}4.3 Kg and 2.9{plus minus}4.4 Kg respectively. However, weight gain at week-52 (1.5{plus minus}5.0 Kg) was no longer significant compared to Failures and Reducers. No confounding factors could explain the significant changes in body weight. Smokers who quit smoking by switching to ECs may limit their post-cessation weight gain, with substantial reversal in weight gain being manifest at late time points.
戒烟 体重增加常与之相关，而体重增加是复吸的最重要原因之一。这是第一项描述被邀请通过改用电子烟戒烟或减少吸烟的吸烟者体重长期变化的研究。在一项邀请吸烟者改用电子烟的随机对照试验中，对传统香烟消费量和体重进行了前瞻性测量。比较了1）高、中、零尼古丁强度产品以及2）持续吸烟失败、减少吸烟和戒烟表型在第12周、第24周和第52周时相对于基线的戒烟后体重变化。还测量了唾液可替宁水平和食欲水平。在高、中、零尼古丁强度产品之间未观察到体重的显著变化。持续吸烟表型之间的差异仅在第12周（p = 0.010）和第24周（p = 0.012）时显著，戒烟者体重分别增加2.4±4.3千克和2.9±4.4千克。然而，与持续吸烟者和减少吸烟者相比，第52周时的体重增加（1.5±5.0千克）不再显著。没有混杂因素可以解释体重的显著变化。通过改用电子烟戒烟的吸烟者可能会限制戒烟后的体重增加，在后期体重增加会有显著逆转。
