Department of Epidemiology and Public Health, University College London, London, UK.
Obesity (Silver Spring). 2012 Oct;20(10):2113-7. doi: 10.1038/oby.2012.61. Epub 2012 Mar 8.
Pericardial fat is emerging as a unique risk factor for coronary disease. We examined the relationship between objectively measured physical activity during free-living and pericardial fat. Participants were 446 healthy men and women (mean age = 66 ± 6 years), without history or objective signs of cardiovascular disease (CVD), drawn from the Whitehall II epidemiological cohort. Physical activity was objectively measured using accelerometers (Actigraph GT3X) worn around the hip during waking hours for 7 consecutive days (average daily wear time = 889 ± 68 min/day), and was classified as sedentary (<200 counts/min (cpm)), light (200-1,998 cpm), or moderate-vigorous physical activity (MVPA; ≥1,999 cpm). Pericardial fat volume was measured in each participant using electron beam computed tomography. Average daily cpm in men was 338.0 ± 145.0 and in women 303.8 ± 130.2. There was an inverse association between average cpm and pericardial fat (B = -0.070, 95% confidence interval (CI), -0.101, -0.040, P < 0.001), and this remained significant after adjusting for age, sex, registered wear time, BMI, lipids, glycemic control, blood pressure, smoking, statins, and social status. Both sedentary time (B = 0.081, 95% CI, 0.022, 0.14) and MVPA (B = -0.362, 95% CI, -0.527, -0.197) were also associated with pericardial fat, although associations for sedentary time did not remain significant after adjustment for MVPA. The inverse association between physical activity and pericardial fat was stronger among overweight and obese adults than in normal weight. Objectively assessed daily activity levels are related to pericardial fat in healthy participants, independently of BMI. This might be an important mechanism in explaining the association between physical activity and CVD prevention.
心包脂肪正成为冠心病的一个独特危险因素。我们研究了自由生活期间客观测量的身体活动与心包脂肪之间的关系。参与者为 446 名健康男性和女性（平均年龄= 66 ± 6 岁），来自白厅 II 流行病学队列，无心血管疾病（CVD）病史或客观征象。使用加速度计（Actigraph GT3X）在清醒期间围绕臀部佩戴 7 天（平均每日佩戴时间= 889 ± 68 分钟/天）来客观测量身体活动，将其分类为久坐（<200 计数/分钟（cpm））、低强度（200-1,998 cpm）或中高强度体力活动（MVPA；≥1,999 cpm）。使用电子束计算机断层扫描（CT）测量每位参与者的心包脂肪量。男性的平均每日 cpm 为 338.0 ± 145.0，女性为 303.8 ± 130.2。平均 cpm 与心包脂肪呈负相关（B = -0.070，95%置信区间（CI），-0.101，-0.040，P < 0.001），在调整年龄、性别、注册佩戴时间、BMI、血脂、血糖控制、血压、吸烟、他汀类药物和社会地位后，这种相关性仍然显著。久坐时间（B = 0.081，95% CI，0.022，0.14）和 MVPA（B = -0.362，95% CI，-0.527，-0.197）也与心包脂肪相关，尽管久坐时间的相关性在调整 MVPA 后不再显著。超重和肥胖成年人中身体活动与心包脂肪之间的负相关关系强于体重正常者。健康参与者中，客观评估的日常活动水平与心包脂肪有关，与 BMI 无关。这可能是解释身体活动与 CVD 预防之间关联的一个重要机制。
