Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium.
Vasc Med. 2012 Apr;17(2):79-84. doi: 10.1177/1358863X12436708. Epub 2012 Mar 8.
This study compares the reliability and reproducibility of flow-mediated dilatation (FMD) and peripheral arterial tonometry (PAT) to assess endothelial function. Eighteen volunteers with coronary heart disease underwent simultaneous testing of FMD by means of brachial artery ultrasound scanning and PAT with the EndoPAT 2000. The subjects underwent both tests twice with an interval of 30 minutes and the same protocol was repeated 2 days later. The within-day variability was lower for the FMD measurements than for the PAT measurements (10% versus 18%; p < 0.05). The between-day variability was similar (11%). A significant correlation was found between PAT and FMD (r = 0.57, p < 0.001). The typical errors of measurements for FMD were lower than those for PAT. In conclusion, in this study, FMD demonstrated the best reliability for the within- and between-day and separate day measurements when compared to PAT.
本研究比较了血流介导的扩张（FMD）和外周动脉张力测定（PAT）评估内皮功能的可靠性和可重复性。18 名冠心病志愿者同时接受肱动脉超声扫描的 FMD 检测和 EndoPAT 2000 的 PAT 检测。受试者在 30 分钟的间隔内进行了两次测试，并且两天后重复了相同的方案。FMD 测量的日内变异性低于 PAT 测量的（10%比 18%；p < 0.05）。日间变异性相似（11%）。发现 PAT 与 FMD 之间存在显著相关性（r = 0.57，p < 0.001）。FMD 的典型测量误差低于 PAT。总之，与 PAT 相比，在本研究中，FMD 在日内、日间和单独日测量时表现出最佳的可靠性。
