Division of Human Nutrition, Department of Food, Environmental and Nutritional Sciences (DeFENS), Università degli Studi di Milano, Milano, Italy.
International Center for the Assessment of Nutritional Status (ICANS), Department of Food, Environmental and Nutritional Sciences (DeFENS), Università degli Studi di Milano, Milano, Italy.
PLoS One. 2022 Dec 1;17(12):e0275132. doi: 10.1371/journal.pone.0275132. eCollection 2022.
Aging is associated with an increased risk of developing cardiovascular disease which is often accompanied by a decline in vascular health and function. Current evidence suggests that berries may have a potential role in the modulation of vascular function, but dietary interventions are still needed to confirm findings, especially in older subjects. In the context of the MIND FoodS HUB project, this study aims to investigate the effect of a single serving of blueberry (250 g of blueberry versus a control product) in a group of older subjects (≥ 60y) through a randomized, controlled, cross-over dietary intervention trial. Specifically, the study evaluates the absorption kinetics of bioactives following the blueberries intake and the effects on markers related to oxidative stress, inflammation, and vascular function analyzed at different time points. By considering a drop-out rate estimate of 25%, at least 20 subjects will be recruited in the study. The study will provide evidence to support the potential beneficial effects of blueberry and its bioactive compounds on vascular function in a group of population more susceptible to vascular dysfunction and to the development of cardiovascular diseases. Moreover, the study will contribute the analysis of several metabolic and functional markers that can support the biological plausibility of the results obtained. Finally, the trial will provide data on the absorption and metabolism of blueberry bioactives which will be used to study their association with the different markers under study. Trail registration: The trial is registered at ISRCTN (http://isrctn.com/ISRCTN18262533); May 7, 2021.
衰老是心血管疾病风险增加的一个因素，而心血管疾病通常伴随着血管健康和功能的下降。目前的证据表明，浆果可能在调节血管功能方面发挥作用，但仍需要饮食干预来证实这些发现，尤其是在老年人中。在 MIND FoodS HUB 项目的背景下，本研究旨在通过一项随机、对照、交叉饮食干预试验，研究蓝莓（250 克蓝莓与对照产品相比）对一组老年受试者（≥60 岁）的影响。具体而言，研究评估了摄入蓝莓后生物活性物质的吸收动力学，以及不同时间点与氧化应激、炎症和血管功能相关的标志物的影响。考虑到 25%的脱落率估计，该研究将招募至少 20 名受试者。该研究将提供证据支持蓝莓及其生物活性化合物对血管功能的潜在有益影响，特别是在更易发生血管功能障碍和心血管疾病的人群中。此外，该研究将分析几种代谢和功能标志物，以支持所获得结果的生物学合理性。最后，该试验将提供关于蓝莓生物活性物质吸收和代谢的数据，这些数据将用于研究它们与研究中不同标志物的关系。试验注册：该试验在 ISRCTN 注册（http://isrctn.com/ISRCTN18262533）；2021 年 5 月 7 日。
