Bortolami Elisa, Slingsby Louisa, Love Emma J
University of Bristol, School of Veterinary Sciences, Bristol UK.
J Feline Med Surg. 2012 Aug;14(8):534-9. doi: 10.1177/1098612X12442038. Epub 2012 Mar 8.
This randomised, blinded, cross-over study investigated the ease of oral transmucosal administration of two formulations of buprenorphine using glucose as a control in 12 cats. The cats received three treatments: buprenorphine multi-dose, buprenorphine and the equivalent volume of glucose 5%. Ease of treatment administration, observation of swallowing, changes in pupil size, sedation, salivation, vomiting, behaviour and food intake were assessed. The data were analysed using MLwiN and multi-level modelling. Ease of administration of buprenorphine multi-dose was statistically different from glucose (P <0.001), and the administration of all treatments became easier over the study periods. Swallowing was not statistically different between groups (P >0.05). Mydriasis was evident after the administration of both formulations of buprenorphine. Sedation, salivation, vomiting, behavioural changes or in-appetence were not observed after any treatment. Cats tolerated oral transmucosal administration of glucose better than buprenorphine multi-dose, while buprenorphine administration was tolerated as well as glucose.
这项随机、双盲、交叉研究在12只猫中，以葡萄糖作为对照，调查了两种丁丙诺啡制剂经口腔黏膜给药的难易程度。这些猫接受了三种治疗：丁丙诺啡多剂量给药、丁丙诺啡给药以及等量的5%葡萄糖。评估了给药的难易程度、吞咽观察、瞳孔大小变化、镇静情况、流涎、呕吐、行为和食物摄入量。使用MLwiN和多层次建模对数据进行了分析。丁丙诺啡多剂量给药的难易程度与葡萄糖在统计学上有差异（P<0.001），并且在研究期间所有治疗的给药都变得更容易。各组之间的吞咽情况在统计学上无差异（P>0.05）。两种丁丙诺啡制剂给药后均出现瞳孔散大。任何治疗后均未观察到镇静、流涎、呕吐、行为变化或食欲不振。猫对经口腔黏膜给予葡萄糖的耐受性优于丁丙诺啡多剂量给药，而丁丙诺啡给药的耐受性与葡萄糖相同。
