恶性疟原虫感染的红细胞会形成自发性红细胞玫瑰花结。
Plasmodium falciparum-infected erythrocytes form spontaneous erythrocyte rosettes.
作者信息
Udomsangpetch R, Wåhlin B, Carlson J, Berzins K, Torii M, Aikawa M, Perlmann P, Wahlgren M
机构信息
Department of Immunology, University of Stockholm, Sweden.
出版信息
J Exp Med. 1989 May 1;169(5):1835-40. doi: 10.1084/jem.169.5.1835.
Abstract
Erythrocytes infected with trophozoites or schizonts of Plasmodium falciparum bind uninfected erythrocytes, leading to rosette formation. Both established laboratory strains and fresh isolates from patients form such rosettes, but at widely different frequencies. IgG preparations from the serum of some P. falciparum-immune donors and heparin inhibited rosette formation. The results indicate that cytoadherence of infected erythrocytes to endothelial cells and rosetting represent distinct genetic traits.
摘要
感染恶性疟原虫滋养体或裂殖体的红细胞会与未感染的红细胞结合，导致玫瑰花结形成。已建立的实验室菌株和来自患者的新鲜分离株都会形成这种玫瑰花结，但频率差异很大。来自一些对恶性疟原虫免疫的供体血清的IgG制剂和肝素可抑制玫瑰花结形成。结果表明，感染的红细胞与内皮细胞的细胞粘附和玫瑰花结形成代表了不同的遗传特征。
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