Toliopoulos Ioannis K, Simos Yannis V, Daskalou Telemachos A, Verginadis Ioannis I, Evangelou Angelos M, Karkabounas Spyros C
Laboratory of Physiology, Faculty of Medicine, University of Ioannina, Ioannina 45110, Greece.
Indian J Exp Biol. 2011 Dec;49(12):904-8.
Platelets aggregation around migrating tumor cells offers protection against the cytotoxic activity of the natural killers cells (NKC). The ascorbic acid in 3 x 10(-3) M concentration completely inhibited platelet aggregation, decreased thromboxane B2 levels, and inhibited the expression of platelet membranic receptor GpIIb/IIIa in non stimulated platelets, and increased the NKC cytotoxicity in an average rate of 105, 61, and 285% in the NKC/targets cells ratios 12.5:1, 25:1 and 50:1 respectively. The results suggest the role of ascorbic acid in increasing the susceptibility of tumor cells to NKC; the ascorbic acid could be used as part of a multidrug therapy to treat diseases which up to now have been treated only through chemotherapy.
迁移的肿瘤细胞周围的血小板聚集可抵御自然杀伤细胞（NKC）的细胞毒性活性。3×10⁻³ M浓度的抗坏血酸完全抑制血小板聚集，降低血栓素B2水平，并抑制未受刺激血小板中血小板膜受体GpIIb/IIIa的表达，且在NKC/靶细胞比例分别为12.5:1、25:1和50:1时，平均以105%、61%和285%的速率增加NKC细胞毒性。结果表明抗坏血酸在增加肿瘤细胞对NKC的敏感性方面具有作用；抗坏血酸可作为多药治疗的一部分，用于治疗目前仅通过化疗治疗的疾病。
