Planès A, Vochelle N, Fagola M, Pebrier A, Guy F
Rev Chir Orthop Reparatrice Appar Mot. 1984;70(1):11-20.
Two series of patients on which total hip or knee prostheses had been inserted were studied. In the first series (150 cases), the patients were treated with low molecular Dextran and subcutaneous sodium heparin at a constant dosage. The Howell test was done every 3 days. The rate of post-operative thrombosis was 14 p. 100. In the second series (100 cases), the patients were treated with low molecular Dextran and subcutaneous sodium heparin with a variable dose adapted to the type of patient. The rate of post-operative thrombosis was only 7 p. 100. The insertion of a knee prosthesis was much more thrombogenic than hip prostheses. In the second series the rate of thrombosis after hip surgery was only 2 p. 100. However a number of complications relating to anticoagulation were a limiting factor of the method.
对两组接受全髋关节或膝关节假体植入的患者进行了研究。在第一组（150例）中，患者接受固定剂量的低分子右旋糖酐和皮下注射肝素治疗。每3天进行一次豪厄尔试验。术后血栓形成率为14‰。在第二组（100例）中，患者接受低分子右旋糖酐和皮下注射肝素治疗，剂量根据患者类型进行调整。术后血栓形成率仅为7‰。膝关节假体植入比髋关节假体植入更易引发血栓形成。在第二组中，髋关节手术后的血栓形成率仅为2‰。然而，一些与抗凝相关的并发症是该方法的限制因素。
