Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Am J Kidney Dis. 2012 Jun;59(6):886-90. doi: 10.1053/j.ajkd.2011.10.056. Epub 2012 Mar 8.
We present a case of a 27-year-old man who received an unrelated donor umbilical cord blood transplant for chronic lymphocytic leukemia. His postsurgery course was complicated by acute kidney injury, hemorrhagic cystitis, and pancytopenia. Transjugular kidney biopsy showed interstitial nephritis. Viral inclusions were present in tubular epithelial cells, and in situ hybridization studies confirmed the presence of adenovirus. Kidney function improved after a short course of cidofovir. Adenovirus-induced interstitial nephritis should be considered in the differential diagnosis in all cases of interstitial nephritis occurring in immunocompromised patients.
我们报告了一例 27 岁男性，因慢性淋巴细胞白血病接受无关供体脐带血移植。他的术后病程复杂，伴有急性肾损伤、出血性膀胱炎和全血细胞减少症。经颈静脉肾活检显示间质性肾炎。管状上皮细胞中有包涵体，原位杂交研究证实腺病毒存在。短期使用西多福韦后肾功能改善。在所有免疫功能低下患者发生间质性肾炎的情况下，都应考虑腺病毒诱导的间质性肾炎作为鉴别诊断。
