Stern R C, Towler S C, White P F, Evers A S
Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110.
Anesth Analg. 1990 Dec;71(6):658-64. doi: 10.1213/00000539-199012000-00014.
Using the rat as an animal model, the elimination kinetics of sevoflurane and halothane from brain, blood, and adipose tissue were compared. Elimination of sevoflurane and halothane from blood and brain was biexponential. The rapid, alpha-elimination rates of sevoflurane from blood and brain were faster than the corresponding rates for halothane. However, the slower beta-elimination rates from brain and blood, as well as the elimination rates from adipose tissue, were similar for both volatile anesthetics. Thus, the potential for residual postoperative impairment from subanesthetic tissue concentrations of halothane and sevoflurane may be similar even though sevoflurane is initially eliminated more rapidly from blood and brain.
以大鼠作为动物模型，比较了七氟烷和氟烷在脑、血液及脂肪组织中的消除动力学。七氟烷和氟烷在血液和脑中的消除呈双指数形式。七氟烷在血液和脑中的快速α消除速率比氟烷相应的速率更快。然而，两种挥发性麻醉药在脑和血液中的较慢β消除速率以及在脂肪组织中的消除速率相似。因此，即使七氟烷最初从血液和脑中消除得更快，但氟烷和七氟烷亚麻醉组织浓度导致术后残留损伤的可能性可能相似。
