使用（19）F MRI 和脉冲应用后的互相关分析测量脑内麻醉摄取动力学。
Measurement of anesthetic uptake kinetics in the brain using (19)F MRI and cross-correlation analysis after pulsed application.
机构信息
Department of Radiology, Section of Medical Physics, Johannes Gutenberg University Medical Center Mainz, Langenbeckstrasse 1, 55131, Mainz, Germany,
出版信息
MAGMA. 2014 Feb;27(1):107-11. doi: 10.1007/s10334-013-0380-9. Epub 2013 Jun 13.
OBJECT
We present a pilot study based on (19)F-MRI to measure fast and slow wash-in and wash-out kinetics of volatile anesthetics in pig brain.
METHOD
The periodic administration of anesthetics in pulsed mode is used to enhance the sensitivity of the anesthetic concentration detection by (19)F-MRI signal. Temporal correlation analysis allows mapping the kinetics time constants.
RESULTS
The clear correlation response to anesthetics concentration changes was found in the brain region in comparison with fatty tissues.
CONCLUSION
The methodology may yield important pharmacological findings on regional effect of the anesthetics in brain and be a step towards human studies.
目的
我们基于 19F-MRI 呈现了一项初步研究，旨在测量猪脑内挥发性麻醉剂的快速和慢速灌注和洗脱动力学。
方法
周期性地以脉冲模式给予麻醉剂，以提高 19F-MRI 信号检测麻醉剂浓度的灵敏度。时间相关分析可用于绘制动力学时间常数图。
结果
与脂肪组织相比，在脑区发现了与麻醉剂浓度变化明显相关的响应。
结论
该方法可能会对大脑中麻醉剂的区域性作用产生重要的药理学发现，并为人体研究迈出一步。
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