• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

使用（19）F MRI 和脉冲应用后的互相关分析测量脑内麻醉摄取动力学。

Measurement of anesthetic uptake kinetics in the brain using (19)F MRI and cross-correlation analysis after pulsed application.

机构信息

Department of Radiology, Section of Medical Physics, Johannes Gutenberg University Medical Center Mainz, Langenbeckstrasse 1, 55131, Mainz, Germany,

出版信息

MAGMA. 2014 Feb;27(1):107-11. doi: 10.1007/s10334-013-0380-9. Epub 2013 Jun 13.

DOI:10.1007/s10334-013-0380-9
PMID:23760558
Abstract

OBJECT

We present a pilot study based on (19)F-MRI to measure fast and slow wash-in and wash-out kinetics of volatile anesthetics in pig brain.

METHOD

The periodic administration of anesthetics in pulsed mode is used to enhance the sensitivity of the anesthetic concentration detection by (19)F-MRI signal. Temporal correlation analysis allows mapping the kinetics time constants.

RESULTS

The clear correlation response to anesthetics concentration changes was found in the brain region in comparison with fatty tissues.

CONCLUSION

The methodology may yield important pharmacological findings on regional effect of the anesthetics in brain and be a step towards human studies.

摘要

目的

我们基于 19F-MRI 呈现了一项初步研究，旨在测量猪脑内挥发性麻醉剂的快速和慢速灌注和洗脱动力学。

方法

周期性地以脉冲模式给予麻醉剂，以提高 19F-MRI 信号检测麻醉剂浓度的灵敏度。时间相关分析可用于绘制动力学时间常数图。

结果

与脂肪组织相比，在脑区发现了与麻醉剂浓度变化明显相关的响应。

结论

该方法可能会对大脑中麻醉剂的区域性作用产生重要的药理学发现，并为人体研究迈出一步。

相似文献

1
Measurement of anesthetic uptake kinetics in the brain using (19)F MRI and cross-correlation analysis after pulsed application.使用（19）F MRI 和脉冲应用后的互相关分析测量脑内麻醉摄取动力学。
MAGMA. 2014 Feb;27(1):107-11. doi: 10.1007/s10334-013-0380-9. Epub 2013 Jun 13.
2
Dynamic (19)F-MRI of pulmonary ventilation using sulfur hexafluoride (SF(6)) gas.使用六氟化硫（SF₆）气体进行肺通气的动态（19）F磁共振成像
Magn Reson Med. 2001 Apr;45(4):605-13. doi: 10.1002/mrm.1082.
3
Fluorine-19 nuclear magnetic resonance imaging and spectroscopy of sevoflurane uptake, distribution, and elimination in rat brain.大鼠脑中七氟醚摄取、分布及消除的氟-19核磁共振成像与波谱分析
Anesthesiology. 1995 Oct;83(4):766-74. doi: 10.1097/00000542-199510000-00016.
4
19F in vivo NMR spectroscopy: a new technique to probe fluorinated anesthetic-tissue interactions.19F 体内核磁共振波谱法：一种探究含氟麻醉剂与组织相互作用的新技术。
Ann N Y Acad Sci. 1991;625:733-42. doi: 10.1111/j.1749-6632.1991.tb33906.x.
5
Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane.鉴定细胞色素P450 2E1为催化七氟烷、异氟烷和甲氧氟烷在人肝微粒体中脱氟的主要酶。
Anesthesiology. 1993 Oct;79(4):795-807. doi: 10.1097/00000542-199310000-00023.
6
In vivo 19F nuclear magnetic resonance brain studies of halothane, isoflurane, and desflurane. Rapid elimination and no abundant saturable binding.氟烷、异氟烷和地氟烷的体内19F核磁共振脑研究。快速消除且无大量可饱和结合。
Ann N Y Acad Sci. 1991;625:707-24. doi: 10.1111/j.1749-6632.1991.tb33904.x.
7
[Let's study pharmacokinetics related to anesthesiology by using computer graphics: inhalation anesthetics].[让我们通过计算机图形学来研究与麻醉学相关的药代动力学：吸入麻醉剂]
Masui. 1990 Jan;39(1):85-92.
8
Automatic delineation of brain regions on MRI and PET images from the pig.猪的 MRI 和 PET 图像上脑区的自动勾画。
J Neurosci Methods. 2018 Jan 15;294:51-58. doi: 10.1016/j.jneumeth.2017.11.008. Epub 2017 Nov 13.
9
19F-nuclear magnetic resonance spectroscopy. Its use in defining molecular sites of anesthetic action.19F-核磁共振波谱学。其在确定麻醉作用分子位点中的应用。
Ann N Y Acad Sci. 1991;625:725-32. doi: 10.1111/j.1749-6632.1991.tb33905.x.
10
Visualization of inert gas wash-out during high-frequency oscillatory ventilation using fluorine-19 MRI.应用氟-19 MRI 观察高频振荡通气时惰性气体的清除。
Magn Reson Med. 2010 Nov;64(5):1478-83. doi: 10.1002/mrm.22528.

引用本文的文献

1
Utilizing native fluorescence imaging, modeling and simulation to examine pharmacokinetics and therapeutic regimen of a novel anticancer prodrug.利用天然荧光成像、建模和模拟来研究一种新型抗癌前药的药代动力学和治疗方案。
BMC Cancer. 2016 Jul 25;16:524. doi: 10.1186/s12885-016-2508-6.
2
30 Years of sodium/X-nuclei magnetic resonance imaging.30 年的钠/X 核磁共振成像。
MAGMA. 2014 Feb;27(1):1-4. doi: 10.1007/s10334-013-0426-z. Epub 2014 Jan 22.

本文引用的文献

1
Fluorine-19 magnetic resonance angiography of the mouse.19 氟磁共振血管造影术在小鼠中的应用。
PLoS One. 2012;7(7):e42236. doi: 10.1371/journal.pone.0042236. Epub 2012 Jul 27.
2
19F magnetic resonance imaging of endogenous macrophages in inflammation.内源性巨噬细胞炎症的 19F 磁共振成像。
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2012 May-Jun;4(3):329-43. doi: 10.1002/wnan.1163. Epub 2012 Feb 21.
3
Visualization of abscess formation in a murine thigh infection model of Staphylococcus aureus by 19F-magnetic resonance imaging (MRI).
19F 磁共振成像（MRI）可视化金黄色葡萄球菌致小鼠大腿感染模型中的脓肿形成。
PLoS One. 2011 Mar 24;6(3):e18246. doi: 10.1371/journal.pone.0018246.
4
Visualization of inert gas wash-out during high-frequency oscillatory ventilation using fluorine-19 MRI.应用氟-19 MRI 观察高频振荡通气时惰性气体的清除。
Magn Reson Med. 2010 Nov;64(5):1478-83. doi: 10.1002/mrm.22528.
5
Comparison of magnetic resonance imaging of inhaled SF6 with respiratory gas analysis.吸入六氟化硫的磁共振成像与呼吸气体分析的比较
Magn Reson Imaging. 2009 May;27(4):549-56. doi: 10.1016/j.mri.2008.08.010. Epub 2008 Oct 17.
6
Double-reference cross-correlation algorithm for separation of the arteries and veins from 3D MRA time series.用于从3D MRA时间序列中分离动脉和静脉的双参考互相关算法。
J Magn Reson Imaging. 2008 Sep;28(3):646-54. doi: 10.1002/jmri.21499.
7
Dynamic (19)F-MRI of pulmonary ventilation using sulfur hexafluoride (SF(6)) gas.使用六氟化硫（SF₆）气体进行肺通气的动态（19）F磁共振成像
Magn Reson Med. 2001 Apr;45(4):605-13. doi: 10.1002/mrm.1082.
8
Separation of arteries and veins in 3D MR angiography using correlation analysis.利用相关性分析在三维磁共振血管造影中分离动脉和静脉。
Magn Reson Med. 2000 Mar;43(3):481-7. doi: 10.1002/(sici)1522-2594(200003)43:3<481::aid-mrm21>3.0.co;2-n.
9
A nuclear magnetic resonance advance. Imaging fluorinated anesthetics in the brain.一项核磁共振技术进展。对大脑中的含氟麻醉剂进行成像。
Anesthesiology. 1995 Oct;83(4):651-3. doi: 10.1097/00000542-199510000-00001.
10
Elimination kinetics of sevoflurane and halothane from blood, brain, and adipose tissue in the rat.大鼠血液、脑和脂肪组织中七氟烷和氟烷的消除动力学
Anesth Analg. 1990 Dec;71(6):658-64. doi: 10.1213/00000539-199012000-00014.