培养的小鼠细胞中的环核苷酸与生长控制：细胞内3':5'-环鸟苷酸浓度变化与细胞周期特定阶段的相关性。
Cyclic nucleotides and growth control in cultured mouse cells: correlation of changes in intracellular 3':5' cGMP concentration with a specific phase of the cell cycle.
作者信息
Seifert W, Rudland P S
出版信息
Proc Natl Acad Sci U S A. 1974 Dec;71(12):4920-4. doi: 10.1073/pnas.71.12.4920.
Abstract
The commencement of cell growth following serum addition to quiescent cultures of mouse fibroblasts is preceded by transient changes in intracellular concentrations of cAMP and cGMP. By artificial depletion of the culture medium for different nutrients, cell growth can be reversibly arrested in various phases of the cell cycle. Here it is shown that the major cGMP increases are only observed when cultures which are arrested in the G(0) phase are stimulated to grow or when synchronized growing cells pass through the G(1) phase. In addition to its concomitant decrease, cAMP exhibits rhythmic changes during the cell cycle. This suggests that the increase in cGMP could act as a specific signal for movement of cells out of the G(0) or G(1) phase of the cell cycle by activating the pleiotypic and mitogenic program of the cell.
摘要
在向静止的小鼠成纤维细胞培养物中添加血清后细胞开始生长之前，细胞内cAMP和cGMP的浓度会发生短暂变化。通过人为耗尽培养基中的不同营养成分，细胞生长可以在细胞周期的各个阶段被可逆地阻滞。本文表明，只有当停滞在G(0)期的培养物被刺激生长时，或者当同步生长的细胞通过G(1)期时，才会观察到主要的cGMP增加。除了伴随的减少外，cAMP在细胞周期中还表现出节律性变化。这表明cGMP的增加可能通过激活细胞的多效性和促有丝分裂程序，作为细胞从细胞周期的G(0)或G(1)期移出的特定信号。
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Cyclic nucleotides and growth control in cultured mouse cells: correlation of changes in intracellular 3':5' cGMP concentration with a specific phase of the cell cycle.培养的小鼠细胞中的环核苷酸与生长控制：细胞内3':5'-环鸟苷酸浓度变化与细胞周期特定阶段的相关性。
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