Department of Toxicology, College of Pharmacy, Chungnam National University, 220 Gung-dong, Daejeon 305-764, Republic of Korea.
Food Chem Toxicol. 2012 Aug;50(8):2923-9. doi: 10.1016/j.fct.2012.04.044. Epub 2012 May 17.
Atopic dermatitis (AD) is a chronic, relapsing, and inflammatory skin disease associated with eczematous symptoms and IgE hyperproduction. Psidium guajava is an important food crop and medicinal plant with anti-oxidant, anti-inflammatory, and anti-allergic activities, supporting its traditional uses. Our previous studies have shown that P. guajava extract inhibits Th2 chemokine expression by suppressing the activation of NF-κB and STAT1 co-stimulated with TNF-α and INF-γ. In this study, we investigated the inhibitory effect of P. guajava water extract (PGW) on 2,4-dinitrochlorobenzene (DNCB)-induced AD-like skin lesions in NC/Nga mice. Treatment of cream containing PGW onto DNCB-induced AD-like skin lesions in NC/Nga mice ameliorated lesion intensity scores, levels of IgE, thymus and activation-regulated chemokine (TARC), TNF-α, and IL-4 in serum and ears. In contrast, PGW increased level of the immunosuppressive cytokine IL-10. Histological analyses demonstrated decreased thickening of the epidermis/dermis as well as dermal infiltration by inflammatory cells. These results suggest that cream containing PGW may be a potential therapeutic modality for AD and adjunctive agent to control pruritus in AD.
特应性皮炎（AD）是一种与湿疹症状和 IgE 高生产相关的慢性、复发性和炎症性皮肤病。番石榴是一种重要的粮食作物和药用植物，具有抗氧化、抗炎和抗过敏活性，支持其传统用途。我们之前的研究表明，番石榴提取物通过抑制 TNF-α 和 INF-γ 刺激的 NF-κB 和 STAT1 的激活，抑制 Th2 趋化因子的表达。在这项研究中，我们研究了番石榴水提取物（PGW）对 NC/Nga 小鼠 2,4-二硝基氯苯（DNCB）诱导的 AD 样皮肤损伤的抑制作用。含有 PGW 的乳膏处理 DNCB 诱导的 NC/Nga 小鼠 AD 样皮肤损伤可改善损伤强度评分、血清和耳部 IgE、胸腺激活调节趋化因子（TARC）、TNF-α 和 IL-4 水平。相比之下，PGW 增加了免疫抑制细胞因子 IL-10 的水平。组织学分析表明，表皮/真皮增厚和真皮炎症细胞浸润减少。这些结果表明，含有 PGW 的乳膏可能是 AD 的一种潜在治疗方法，也是控制 AD 瘙痒的辅助药物。
