Massachusetts Veterans Epidemiology and Research Information Center, Boston VA Healthcare System, USA.
Clin Cardiol. 2012;35(7):437-42. doi: 10.1002/clc.21978. Epub 2012 Mar 8.
We sought to determine whether lifestyle modifications are associated with high-density lipoprotein cholesterol (HDL-C) change in a cohort with long-term follow-up.
Changes in alcohol consumption, smoking, or body mass index (BMI) are associated with within-individual changes in HDL-C.
We selected 1420 men with ≥2 HDL-C measurements from the US Department of Veterans Affairs Normative Aging Study (NAS). Changes in HDL-C (in milligrams/deciliter) over a 3-year period were calculated for each pair of exams. For each interval of HDL-C change, lifestyle exposures were categorized: participants maintained a stable BMI >25 kg/m(2) (reference) or ≤25 kg/m(2) since the previous exam, or increased or decreased BMI; participants were actively smoking at both exams (reference), nonsmokers at both exams, quit, or initiated smoking between exams; and participants maintained alcohol intake of <2 (reference) or ≥2 drinks daily since the previous exam, or increased or decreased alcohol intake. Longitudinal analysis was used to examine the relationship between the lifestyle change categories and 3-year change in HDL-C for each interval, adjusting for comorbidities, lipids, and cholesterol medication.
Participants were followed for approximately 14.3 years. Increases in HDL-C were associated with maintaining alcohol intake of ≥2 drinks daily (mean HDL-C increase, 0.86; P = 0.02), increasing alcohol intake from <2 to ≥2 drinks daily (mean, 2.53; P = 0.0003), and with maintaining a BMI of ≤25 kg/m(2) (mean, 0.71; P = 0.04).
Increases in alcohol consumption, maintaining moderate alcohol intake, and maintaining BMI ≤25 kg/m(2) were associated with significant 3-year increases in HDL-C.
我们旨在确定在长期随访的队列中，生活方式改变是否与高密度脂蛋白胆固醇（HDL-C）的变化相关。
饮酒、吸烟或体重指数（BMI）的变化与个体内 HDL-C 的变化相关。
我们从美国退伍军人事务部正常老化研究（NAS）中选择了 1420 名至少有两次 HDL-C 测量值的男性。每对检查之间计算 HDL-C（毫克/分升）的 3 年变化。对于每个 HDL-C 变化间隔，将生活方式暴露分类：参与者自上次检查以来保持稳定的 BMI>25kg/m(2)（参考）或≤25kg/m(2)，或增加或减少 BMI；参与者在两次检查时均吸烟（参考），两次检查时均不吸烟，戒烟或在检查之间开始吸烟；参与者自上次检查以来保持酒精摄入量<2（参考）或≥2 杯/天，或增加或减少酒精摄入量。纵向分析用于检查每个间隔的生活方式改变类别与 3 年 HDL-C 变化之间的关系，同时调整合并症、脂质和胆固醇药物。
参与者平均随访约 14.3 年。HDL-C 的增加与保持每日≥2 份酒精摄入（平均 HDL-C 增加 0.86；P=0.02）、从<2 份增加到每日≥2 份酒精摄入（平均，2.53；P=0.0003）以及保持 BMI≤25kg/m(2)（平均，0.71；P=0.04）相关。
饮酒量增加、保持适量饮酒和保持 BMI≤25kg/m(2)与 HDL-C 的 3 年显著增加相关。
