Perova N V, Oganov R G, Williams D H, Irving S H, Abernathy J R, Deev A D, Shestov D B, Zhukovsky G S, Davis C E, Tyroler H A
National Center for Preventive Medicine of the Russian Federation, Moscow.
Ann Epidemiol. 1995 May;5(3):179-85. doi: 10.1016/1047-2797(94)00104-2.
Previous reports from the Russian Lipid Research Clinics (LRC) study showed no association between the level of high-density-lipoprotein (HDL) cholesterol and mortality from coronary heart disease (CHD), while US LRC data indicated a strong negative association between HDL cholesterol and CHD mortality. This report investigated the association of HDL cholesterol and mortality in these same population samples with follow-up extended to 12 years. The association between HDL cholesterol and mortality remained inverse and significant in the US sample. In the Russian sample, high levels of HDL cholesterol were associated with higher risk of all-cause and cancer mortality, although adjustment for known risk factors reduced the strength of the association. The association between HDL cholesterol and CHD mortality was negative in the Russian sample, although the strength of the association was less than that for the US sample. Extended follow-up reduced the difference in the association between HDL cholesterol and mortality between the two countries; however, important differences remained. Further research will be required to clearly determine the cause for their differences.
俄罗斯脂质研究临床中心（LRC）之前的报告显示，高密度脂蛋白（HDL）胆固醇水平与冠心病（CHD）死亡率之间无关联，而美国LRC的数据则表明HDL胆固醇与CHD死亡率之间存在强烈的负相关。本报告调查了这些相同人群样本中HDL胆固醇与死亡率之间的关联，并将随访期延长至12年。在美国样本中，HDL胆固醇与死亡率之间的关联仍然呈负相关且具有显著性。在俄罗斯样本中，HDL胆固醇水平较高与全因死亡率和癌症死亡率风险较高相关，尽管对已知风险因素进行调整后减弱了这种关联的强度。在俄罗斯样本中，HDL胆固醇与CHD死亡率之间的关联呈负相关，尽管这种关联的强度低于美国样本。延长随访期缩小了两国之间HDL胆固醇与死亡率关联的差异；然而，重要差异依然存在。需要进一步研究以明确确定其差异的原因。
