Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore.
Immunol Res. 2012 Sep;53(1-3):162-7. doi: 10.1007/s12026-012-8271-0.
Genetic and non-genetic factors can alter the action of a medicinal drug, resulting in a wide range of responses in different individuals. Among the many potential side effects of therapies, a drug eruption is an adverse drug reaction in the skin. Genetic associations between HLA haplotype and drug eruption have been reported, and immune responses against latent herpesvirus have also been implicated in some forms of this syndrome. We believe that it is essential to understand the immune mechanisms by which some drugs induce hypersensitivity so that we can better target these pathways to limit drug side effects. The identification of patient risk factors for drug eruptions will allow the rational design of novel immunotherapies for these life-threatening reactions, and the development of alternative interventions for high-risk patients.
遗传和非遗传因素可改变药物的作用，导致不同个体出现广泛的反应。在治疗的众多潜在副作用中，药物疹是皮肤的一种药物不良反应。已有报道称 HLA 单倍型与药物疹之间存在遗传关联，某些形式的这种综合征也与针对潜伏疱疹病毒的免疫反应有关。我们认为，了解某些药物引发过敏反应的免疫机制至关重要，这样我们才能更好地针对这些途径来限制药物副作用。确定药物疹患者的风险因素将有助于为这些危及生命的反应设计合理的新免疫疗法，并为高风险患者开发替代干预措施。
