Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, #03 Immunos, Biopolis, Singapore.
Immunol Res. 2012 Sep;53(1-3):168-81. doi: 10.1007/s12026-012-8292-8.
The migration of neutrophils between tissue compartments is an important aspect of innate immune surveillance. This process is regulated by a cascade of cellular and molecular signals to avoid unnecessary crowding of neutrophils at the periphery, to allow rapid mobilization of neutrophils in response to inflammatory stimuli, and to return to a state of homeostasis after the response. Intravital microscopy approaches have been fundamental in unraveling many aspects of neutrophil behavior, providing important mechanistic information on the processes involved in basal and disease states. Here, we provide a broad overview of the current state of research on neutrophil biology, describing the processes in the typical life cycle of neutrophils, from their first appearance in the bone marrow until their eventual destruction. We will focus on novel aspects of neutrophil behavior, which had previously been elusive until their recent elucidation by advanced intravital microscopy techniques.
中性粒细胞在组织间隙之间的迁移是先天免疫监视的一个重要方面。这个过程受到一系列细胞和分子信号的调节，以避免外周中性粒细胞的不必要聚集，允许中性粒细胞在炎症刺激下迅速动员，并在反应后恢复到平衡状态。活体显微镜方法在揭示中性粒细胞行为的许多方面发挥了重要作用，为基础和疾病状态涉及的过程提供了重要的机制信息。在这里，我们提供了对中性粒细胞生物学研究现状的广泛概述，描述了中性粒细胞典型生命周期中的各个过程，从它们首次出现在骨髓到最终破坏。我们将重点介绍中性粒细胞行为的新方面，这些方面以前是难以捉摸的，直到最近通过先进的活体显微镜技术才得以阐明。
