Bradford School of Pharmacy, University of Bradford, Bradford, BD7 1DP, UK.
Phytother Res. 2012 Dec;26(12):1793-9. doi: 10.1002/ptr.4651. Epub 2012 Mar 9.
In the search for biologically active plant species, many studies have shown that an ethnopharmacological approach is more effective than a random collection. In order to determine whether this is true in the case of plant species used for the treatment of malaria in Orissa, India, the antiplasmodial activities of extracts prepared from 25 traditionally used species were compared with those of 25 species collected randomly. As expected, plant species used traditionally for the treatment of malaria were more likely to exhibit antiplasmodial activity (21 species (84%) active against Plasmodium falciparum strain 3D7) than plant species collected randomly (9 species (32%)). However, of the nine active randomly collected species, eight had not previously been reported to possess antiplasmodial activity while one inactive species had been reported to be active in another study. Of the 21 active species of traditional antimalarial treatments, only six had been reported previously. This study suggests that while the selection of traditional medicinal plants is more predictive of antiplasmodial study, random collections may still be of value for the identification of new antiplasmodial species.
在寻找具有生物活性的植物物种的过程中，许多研究表明，与随机采集相比，采用民族药理学方法更为有效。为了确定在印度奥里萨邦用于治疗疟疾的植物物种的情况下是否如此，比较了从 25 种传统使用的物种中制备的提取物的抗疟活性与从 25 种随机采集的物种中制备的提取物的抗疟活性。正如预期的那样，传统上用于治疗疟疾的植物物种更有可能表现出抗疟活性（21 种（84%）对恶性疟原虫 3D7 株有效），而随机采集的植物物种则不然（9 种（32%））。然而，在这 9 种具有抗疟活性的随机采集的物种中，有 8 种以前没有报道过具有抗疟活性，而一种无活性的物种在另一项研究中被报道具有活性。在 21 种传统抗疟治疗的活性物种中，以前只报道过 6 种。这项研究表明，虽然传统药用植物的选择更能预测抗疟研究，但随机采集仍然可能有助于鉴定新的抗疟物种。
