Department of Chemistry, University of Washington, Seattle, 98105, USA.
Angew Chem Int Ed Engl. 2012 Apr 16;51(16):3953-6. doi: 10.1002/anie.201200480. Epub 2012 Mar 7.
No longer a hindrance: copper-catalyzed electrophilic amination of aryl boronic esters is accomplished under mild reaction conditions using 2.5-5.0 mol % of a catalyst derived from copper tert-butoxide and Xantphos ligand. The reaction tolerates a wide range of functional groups and can be used to prepare some of the most hindered anilines made to date.
使用铜 tert-丁氧化物和 Xantphos 配体衍生的催化剂，在温和的反应条件下，芳基硼酸酯的铜催化亲电胺化反应可在 2.5-5.0 mol%的催化剂用量下完成。该反应可耐受广泛的官能团，可用于制备迄今为止合成的一些位阻最大的苯胺。
