乌桕中的细胞毒性二萜。

Cytotoxic diterpenoids from Sapium insigne.

机构信息

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.

出版信息

J Nat Prod. 2012 Apr 27;75(4):722-7. doi: 10.1021/np300004y. Epub 2012 Mar 12.

DOI:10.1021/np300004y

PMID:22409148

Abstract

Chemical investigation into the twigs and leaves of Sapium insigne afforded seven new diterpenoids, sapinsignoids A-G (1-7), together with 10 known diterpenoids. The structures of 1-7 were assigned on the basis of detailed spectroscopic analysis and chemical degradation. Compounds 1-4 exhibited significant cytotoxicity against the A-549 tumor cell line (IC(50) 0.2-1.8 μM), while compounds 1-3 showed moderate cytotoxicity against the HL-60 cell line (IC(50) 2.7-6.5 μM).

摘要

对乌桕的嫩枝和叶子进行的化学研究得到了 7 种新的二萜类化合物，即 sapinsignoids A-G（1-7），以及 10 种已知的二萜类化合物。基于详细的光谱分析和化学降解，确定了 1-7 的结构。化合物 1-4 对 A-549 肿瘤细胞系表现出显著的细胞毒性（IC（50）为 0.2-1.8 μM），而化合物 1-3 对 HL-60 细胞系表现出中等的细胞毒性（IC（50）为 2.7-6.5 μM）。