腺梗豨莶中二萜类化合物的结构与细胞毒性

Structure and cytotoxicity of diterpenoids from Isodon adenolomus.

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People's Republic of China.

出版信息

J Nat Prod. 2011 May 27;74(5):1213-20. doi: 10.1021/np200140j. Epub 2011 May 2.

DOI:10.1021/np200140j

PMID:21534539

Abstract

Twelve new diterpenoids, isoadenolins A-L (1-12), and 24 known ones were isolated from the aerial parts of Isodon adenolomus. Their structures were identified using spectroscopic data, and the absolute configurations of 1 and 14 were determined by single-crystal X-ray diffraction. Selected compounds were evaluated for their in vitro cytotoxicity against human tumor HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines. Compounds 9, 13-16, and 21 showed significant inhibitory effects on all five cells, with IC50 values in the range 0.7-9.7 μM.

摘要

从腺梗豨莶的地上部分分离得到 12 个新的二萜类化合物，即异腺梗豨莶宁 A-L（1-12），和 24 个已知化合物。采用光谱数据鉴定了它们的结构，并通过单晶 X 射线衍射确定了 1 和 14 的绝对构型。对所选化合物进行了体外细胞毒性评价，测试了它们对人肿瘤 HL-60、SMMC-7721、A-549、MCF-7 和 SW-480 细胞系的抑制活性。化合物 9、13-16 和 21 对所有 5 种细胞均表现出显著的抑制作用，IC50 值在 0.7-9.7 μM 范围内。