INRA and AgroParis Tech, UMR 1319, MICALIS, Neurobiology of Ingestive Behavior, Jouy-en-Josas Cedex, France.
Br J Nutr. 2012 Sep;108(5):778-93. doi: 10.1017/S0007114512000529. Epub 2012 Mar 13.
The gastrointestinal peptides are classically known as short-term signals, primarily inducing satiation and/or satiety. However, accumulating evidence has broadened this view, and their role in long-term energy homeostasis and the development of obesity has been increasingly recognised. In the present review, the recent research involving the role of satiation signals, especially ghrelin, cholecystokinin, glucagon-like peptide 1 and peptide YY, in the development and treatment of obesity will be discussed. Their activity, interactions and release profile vary constantly with changes in dietary and energy influences, intestinal luminal environment, body weight and metabolic status. Manipulation of gut peptides and nutrient sensors in the oral and postoral compartments through diet and/or changes in gut microflora or using multi-hormone 'cocktail' therapy are among promising approaches aimed at reducing excess food consumption and body-weight gain.
胃肠肽通常被认为是短期信号，主要作用是诱导饱腹感和/或满足感。然而，越来越多的证据拓宽了这一观点，其在长期能量平衡和肥胖发展中的作用也得到了越来越多的认可。在本综述中，将讨论饱腹感信号（特别是胃饥饿素、胆囊收缩素、胰高血糖素样肽 1 和肽 YY）在肥胖发展和治疗中的最新研究。它们的活性、相互作用和释放模式会随着饮食和能量影响、肠道腔环境、体重和代谢状态的变化而不断变化。通过饮食和/或改变肠道微生物群或使用多激素“鸡尾酒”疗法来操纵口腔和口后段的肠道肽和营养传感器，是减少过量食物摄入和体重增加的有前途的方法之一。
