State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
Int J Tuberc Lung Dis. 2012 May;16(5):674-80. doi: 10.5588/ijtld.11.0429. Epub 2012 Mar 7.
Peak expiratory flow (PEF) measurement is less expensive and requires fewer skills than spirometry testing. It is thus expected to be a reasonable substitute for spirometry in airflow obstruction screening when spirometry is unavailable.
To evaluate the validation of PEF measurement in the detection of airflow obstruction using newly established regression equations.
The PEFs of 553 'normal' participants aged 40-85 years were measured using mechanical devices. Based on these data, regression equations were generated to predict normal PEF values. Data were then collected from 3379 subjects. The specificity and sensitivity of the different predicted PEF cut-off points for detecting airflow obstruction were evaluated by spirometry, based on previously generated regression equations.
Using newly established reference values for PEF, PEF had higher sensitivity and specificity than the questionnaire in detection of airflow obstruction. That PEF < 80% of predicted was more effective in the detection of airflow obstruction was confirmed by the lower limit of normal of forced expiratory volume in 1 second/forced vital capacity, Global Initiative for Chronic Obstructive Lung Disease (GOLD), and GOLD plus symptom, with a sensitivity of 78.7%, 76.8%, 85.3% and a specificity of 81.9%, 83.8%, 81.4%, respectively.
Mechanical PEF may be a reasonable method of screening for airflow obstruction in settings where spirometry is unavailable.
与肺活量测定相比，呼气峰流速（PEF）测量的费用更低，所需技能更少。因此，当肺活量测定不可用时，预计它将成为气流阻塞筛查中替代肺活量测定的合理方法。
使用新建立的回归方程评估 PEF 测量在检测气流阻塞中的验证。
使用机械设备测量了 553 名 40-85 岁“正常”参与者的 PEF。基于这些数据，生成了回归方程来预测正常 PEF 值。然后从 3379 名受试者中收集数据。根据先前生成的回归方程，使用不同预测的 PEF 截止值评估了用于检测气流阻塞的特异性和敏感性。
使用新建立的 PEF 参考值，PEF 在检测气流阻塞方面的敏感性和特异性均高于问卷。PEF<预测值的 80%在检测气流阻塞方面更有效，这一点得到了一秒用力呼气量/用力肺活量、全球倡议慢性阻塞性肺疾病（GOLD）和 GOLD 加症状的正常下限的证实，其敏感性分别为 78.7%、76.8%、85.3%，特异性分别为 81.9%、83.8%、81.4%。
在无法进行肺活量测定的情况下，机械 PEF 可能是一种筛查气流阻塞的合理方法。
