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中国北京市基层医疗机构慢性阻塞性肺疾病筛查工具的比较研究。

Comparative Study on Chronic Obstructive Pulmonary Disease Screening Tools in Primary Healthcare Institutions in Beijing, China.

机构信息

Department of General Practice, Donghuashi Community Health Service Center, Beijing, People's Republic of China.

Department of General Practice, Peking University Health Science Center, Beijing, People's Republic of China.

出版信息

Int J Chron Obstruct Pulmon Dis. 2023 Aug 17;18:1773-1781. doi: 10.2147/COPD.S419550. eCollection 2023.

Abstract

BACKGROUND

Chronic obstructive pulmonary disease (COPD) has a high incidence rate in China, but the diagnosis rate remains insufficient. This study aimed to explore and compare COPD screening tools for primary healthcare institutions in China.

PURPOSE

Exploring COPD Screening Tools and Their Combined Use for Primary Healthcare Institutions in China.

PATIENTS AND METHODS

From September 2022 to March 2023, a screening for COPD was conducted among residents aged 35 years and above in primary healthcare institutions in Beijing, China. The screening involved the use of the CAPTURE scale, COPD-SQ scale, and peak expiratory flow rate test. Any positive results from these screening tests were followed by further pulmonary function testing to confirm the diagnosis. Sensitivity, specificity, positive predictive value, negative predictive value, and receiver operating characteristic (ROC) curves were calculated for each screening tool alone and in combination.

RESULTS

A total of 986 individuals completed the screening tests. The positive rates for the CAPTURE scale, COPD-SQ scale, and peak flow meter screening were 41.78%, 29.11%, and 52.03%, respectively. Of the participants, 166 (24.09%) underwent pulmonary function tests, with an average age of 61.69±13.68 years. The peak flow meter screening showed the highest sensitivity (83.78%) when used alone, while the COPD-SQ scale exhibited the best specificity (59.69%), positive predictive value (31.58%), and negative predictive value (58.56%). Significant differences (P<0.05) were observed between any two of the three screening tools. Among the combinations, the peak flow meter screening + COPD-SQ scale showed the highest accuracy, with a Youden index of 0.277 and an AUC of 0.638.

CONCLUSION

There is variation in the accuracy of existing screening tools for COPD when used alone. For primary healthcare institutions, the optimal COPD screening tool is the combination of peak flow meter screening and the COPD-SQ questionnaire. If limited by screening equipment conditions, the COPD-SQ questionnaire can be used alone for screening.

摘要

背景

在中国,慢性阻塞性肺疾病(COPD)的发病率很高,但诊断率仍然不足。本研究旨在探索和比较中国基层医疗机构的 COPD 筛查工具。

目的

探索中国基层医疗机构的 COPD 筛查工具及其联合应用。

患者和方法

2022 年 9 月至 2023 年 3 月,对中国北京基层医疗机构的 35 岁及以上居民进行 COPD 筛查。筛查采用 CAPTURE 量表、COPD-SQ 量表和呼气峰流速仪测试。对这些筛查测试的任何阳性结果进行进一步的肺功能测试以确认诊断。计算了每个筛查工具单独使用和联合使用的敏感性、特异性、阳性预测值、阴性预测值和受试者工作特征(ROC)曲线。

结果

共有 986 人完成了筛查测试。CAPTURE 量表、COPD-SQ 量表和呼气峰流速仪筛查的阳性率分别为 41.78%、29.11%和 52.03%。在这些参与者中,有 166 人(24.09%)接受了肺功能测试,平均年龄为 61.69±13.68 岁。单独使用时,呼气峰流速仪筛查的敏感性最高(83.78%),而 COPD-SQ 量表的特异性(59.69%)、阳性预测值(31.58%)和阴性预测值(58.56%)最好。三种筛查工具中任意两种之间均存在显著差异(P<0.05)。在组合中,呼气峰流速仪筛查+COPD-SQ 量表的准确性最高,Youden 指数为 0.277,AUC 为 0.638。

结论

现有 COPD 筛查工具单独使用时准确性存在差异。对于基层医疗机构,最佳的 COPD 筛查工具是呼气峰流速仪筛查和 COPD-SQ 问卷的联合应用。如果受筛查设备条件限制,也可以单独使用 COPD-SQ 问卷进行筛查。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f913/10441650/0961bc53241f/COPD-18-1773-g0001.jpg

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