西酞普兰、QT间期延长与尖端扭转型室速
Citalopram, QTc Prolongation, and Torsades de Pointes.
作者信息
Tampi Rajesh R, Balderas Michael, Carter Kathleen V, Tampi Deena J, Moca Marian, Knudsen Amy, May Jacquelyn
机构信息
Department of Psychiatry, Regional Academic Health Center, University of Texas Health Science Center at San Antonio, Harlingen, TX (RRT, MM, AK, JM).
Department of Internal Medicine, Valley Baptist Hospital, University of Texas Health Science Center at San Antonio, Harlingen, TX (MB).
出版信息
Psychosomatics. 2015 Jan-Feb;56(1):36-43. doi: 10.1016/j.psym.2014.09.002. Epub 2014 Sep 6.
OBJECTIVES
The aim of this systematic review is to identify case reports of citalopram use resulting in QTc prolongation, torsades de pointes, or both, in the medical literature.
METHODS
A literature search was conducted of PubMed, MEDLINE, EMBASE, Scopus, and PsycINFO databases for case reports published in any language that reported the relationship between citalopram use and the development of QTc prolongation or torsades de pointes or both. In addition, bibliographic databases of published articles were searched for additional cases.
RESULTS
A total of 18 case reports of citalopram use resulting in QTc prolongation were identified. Of these, 10 cases were also associated with the development of torsades de pointes. A total of 14 cases occurred in women and 4 in men. There were 7 cases involving an overdose with citalopram. Of the 18 cases, 12 occurred in individuals who were aged <60 years and 6 were in individuals aged >60 years. In 8 of the 18 cases, the individuals were taking a dose between 20 and 60mg of citalopram in a day. Hypertension was the most common comorbid medical condition, as seen in 5 of the cases.
CONCLUSIONS
QTc prolongation or torsades de pointes are infrequently reported adverse effects associated with citalopram use.
目的
本系统评价的目的是在医学文献中识别使用西酞普兰导致QTc延长、尖端扭转型室速或两者兼有的病例报告。
方法
对PubMed、MEDLINE、EMBASE、Scopus和PsycINFO数据库进行文献检索，查找以任何语言发表的报告西酞普兰使用与QTc延长或尖端扭转型室速或两者发生之间关系的病例报告。此外，还在已发表文章的书目数据库中搜索其他病例。
结果
共识别出18例使用西酞普兰导致QTc延长的病例报告。其中，10例还伴有尖端扭转型室速的发生。女性共14例，男性4例。有7例涉及西酞普兰过量。在这18例中，12例发生在年龄<60岁的个体中，6例发生在年龄>60岁的个体中。在18例中的8例中，个体每日服用20至60毫克西酞普兰。高血压是最常见的合并症，5例病例中可见。
结论
QTc延长或尖端扭转型室速是与使用西酞普兰相关的罕见不良反应。
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