Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD 20892-2670, USA.
Prog Neuropsychopharmacol Biol Psychiatry. 2012 Aug 7;38(2):127-33. doi: 10.1016/j.pnpbp.2012.02.014. Epub 2012 Mar 4.
A better understanding of the neural underpinnings of bipolar disorder (BD) can be obtained by examining brain activity in symptom-free individuals at risk for BD. This study examined the neural correlates of motor inhibition in a sample of symptom-free youths at familial risk for BD.
19 euthymic youths with BD, 13 asymptomatic youths with a first-degree relative with BD, and 21 healthy comparison children completed the stop signal task in a 3 T scanner.
Children at familial risk for BD exhibited increased putamen activation during unsuccessful inhibition that distinguished them from both healthy and BD children. Youths with BD exhibited reduced activation of the right nucleus accumbens during unsuccessful inhibition as compared to the other participant groups.
Striatal activation patterns differ between youths at risk for BD and healthy comparison children during a motor inhibition task.
通过研究无症状、有双相障碍（BD）家族史个体的大脑活动，可以更好地了解 BD 的神经基础。本研究在一个无症状、有 BD 家族史的青少年样本中，检测了运动抑制的神经相关性。
19 名病情稳定的 BD 青少年、13 名无症状的一级亲属有 BD 的青少年和 21 名健康的对照儿童在 3T 扫描仪中完成了停止信号任务。
有 BD 家族史的风险青少年在不成功的抑制期间表现出纹状体的激活增加，这使他们与健康和 BD 儿童区分开来。与其他参与者群体相比，BD 青少年在不成功的抑制期间右侧伏隔核的激活减少。
在运动抑制任务中，BD 风险青少年和健康对照儿童的纹状体激活模式不同。
