Nutrition and Obesity Group, Department of Nutrition and Food Science, University of the Basque Country (UPV/EHU) and Lucio Lascaray Research Institute, 01006 Vitoria-Gasteiz, Spain.
CIBEROBN Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, 01006 Vitoria-Gasteiz, Spain.
Nutrients. 2023 Apr 19;15(8):1960. doi: 10.3390/nu15081960.
Non-alcoholic fatty liver disease (NAFLD) is considered the most common chronic liver alteration whose prevalence is increasing in Western countries. Microalgae and macroalgae have attracted great interest due to the high content in bioactive compounds with beneficial effects on health. The aim of the present study is to assess the potential interest of extracts rich in proteins obtained from the microalgae and and the macroalga in the prevention of lipid accumulation in AML-12 hepatocytes. Toxicity was not observed at any of the tested doses. Both microalgae and the macroalga were effective in preventing triglyceride accumulation, with being the most effective one. Although the three algae extracts were able to increase different catabolic pathways involved in triglyceride metabolism, the mechanisms underlying the anti-steatotic effect were different in each algae extract. In conclusion, the present study demonstrates that , and extracts are able to partially prevent the accumulation of triglycerides induced by palmitic acid in cultured hepatocytes, a model used to mimic the steatosis induced in liver by dietary patterns rich in saturated fat.
非酒精性脂肪性肝病（NAFLD）被认为是最常见的慢性肝改变，其在西方国家的患病率正在上升。由于具有有益健康的生物活性化合物含量高，微藻和海藻引起了极大的兴趣。本研究旨在评估从微藻 和 和大型海藻 中提取的富含蛋白质的提取物在预防 AML-12 肝细胞中脂质积累方面的潜在兴趣。在任何测试剂量下都没有观察到毒性。两种微藻和大型海藻都能有效预防甘油三酯的积累，其中 效果最好。尽管三种藻类提取物都能增加不同的参与甘油三酯代谢的分解代谢途径，但每种藻类提取物的抗脂肪变性作用的机制不同。总之，本研究表明， 、 和 提取物能够部分预防由棕榈酸诱导的培养肝细胞中甘油三酯的积累，该模型用于模拟富含饱和脂肪的饮食模式引起的肝脏脂肪变性。
