Public Health Agency, Health Department of Catalonia, Roc Boronat 83-85, Barcelona 08005, Spain.
Prev Med. 2012 Jul;55(1):72-7. doi: 10.1016/j.ypmed.2012.02.015. Epub 2012 Mar 4.
The vaccination coverage required to establish herd immunity was determined by taking into account the number of secondary cases per infected case (R(o)) and the vaccine effectiveness.
The required percentage that would have been required to establish herd immunity against previous influenza viruses ranged from 13% to 100% for the 1918-19, 1957-58, 1968-69 and 2009-10 pandemic viruses, and from 30% to 40% for the 2008-09 epidemic virus. The objectives of vaccination coverage proposed in the United States - 80% in healthy persons and 90% in high-risk persons - are sufficient to establish herd immunity, while those proposed in Europe - only 75% in elderly and high-risk persons - are not sufficient. The percentages of vaccination coverage registered in the United States and Europe are not sufficient to establish herd immunity.
The influenza vaccination coverage must be increased in the United States and Europe in order to establish herd immunity. It is necessary to develop new influenza prevention messages based on herd immunity.
1）确定建立群体免疫所需的流感疫苗接种覆盖率，2）评估美国和欧洲提出的疫苗接种覆盖率百分比是否足以建立群体免疫。
通过考虑每例感染病例（R(o)）的继发病例数和疫苗有效性，确定建立群体免疫所需的疫苗接种覆盖率。
为了针对以往的流感病毒建立群体免疫，需要的百分比范围为 1918-19 年、1957-58 年、1968-69 年和 2009-10 年大流行病毒的 13%至 100%，以及 2008-09 年流行病毒的 30%至 40%。美国提出的疫苗接种覆盖率目标 - 健康人群 80%，高风险人群 90% - 足以建立群体免疫，而欧洲提出的目标 - 仅老年和高风险人群 75% - 则不足以建立群体免疫。美国和欧洲登记的疫苗接种覆盖率百分比不足以建立群体免疫。
美国和欧洲必须增加流感疫苗接种覆盖率，以建立群体免疫。有必要根据群体免疫制定新的流感预防信息。
