• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Pronounced reduction of total neuron number in mediodorsal thalamic nucleus and nucleus accumbens in schizophrenics.

作者信息

Pakkenberg B

机构信息

Neurological Research Laboratory, Hvidovre Hospital, Copenhagen, Denmark.

出版信息

Arch Gen Psychiatry. 1990 Nov;47(11):1023-8. doi: 10.1001/archpsyc.1990.01810230039007.

DOI:10.1001/archpsyc.1990.01810230039007
PMID:2241504
Abstract

Using a new and unbiased stereological technique, the total numbers of neuron and glial cells in the mediodorsal thalamic nucleus and the nucleus accumbens were found to be significantly reduced in schizophrenic patients compared with controls. The total neuron and glial cell number in the ventral pallidum and in the basolateral nucleus of amygdala did not differ in the two groups.

摘要

相似文献

1
Pronounced reduction of total neuron number in mediodorsal thalamic nucleus and nucleus accumbens in schizophrenics.
Arch Gen Psychiatry. 1990 Nov;47(11):1023-8. doi: 10.1001/archpsyc.1990.01810230039007.
2
Leucotomized schizophrenics lose neurons in the mediodorsal thalamic nucleus.
Neuropathol Appl Neurobiol. 1993 Oct;19(5):373-80. doi: 10.1111/j.1365-2990.1993.tb00457.x.
3
Ventral striatopallidothalamic projection: IV. Relative involvements of neurochemically distinct subterritories in the ventral pallidum and adjacent parts of the rostroventral forebrain.腹侧纹状体苍白球丘脑投射:IV. 腹侧苍白球及嘴腹侧前脑相邻部分中神经化学性质不同的亚区域的相对参与情况
J Comp Neurol. 1996 Jan 8;364(2):340-62. doi: 10.1002/(SICI)1096-9861(19960108)364:2<340::AID-CNE11>3.0.CO;2-T.
4
Modulation of dorsal thalamic cell activity by the ventral pallidum: its role in the regulation of thalamocortical activity by the basal ganglia.腹侧苍白球对背侧丘脑细胞活动的调节:其在基底神经节对丘脑皮质活动调节中的作用。
Synapse. 1994 Oct;18(2):104-27. doi: 10.1002/syn.890180205.
5
New stereological method for obtaining unbiased and efficient estimates of total nerve cell number in human brain areas. Exemplified by the mediodorsal thalamic nucleus in schizophrenics.
APMIS. 1989 Aug;97(8):677-81. doi: 10.1111/j.1699-0463.1989.tb00462.x.
6
Elevated neuron number in the limbic thalamus in major depression.重度抑郁症患者边缘丘脑神经元数量增加。
Am J Psychiatry. 2004 Jul;161(7):1270-7. doi: 10.1176/appi.ajp.161.7.1270.
7
Position of the ventral pallidum in the rat prefrontal cortex-basal ganglia circuit.腹侧苍白球在大鼠前额叶皮质 - 基底神经节回路中的位置。
Neuroscience. 1997 Sep;80(2):523-34. doi: 10.1016/s0306-4522(97)00002-x.
8
Volume, neuron density and total neuron number in five subcortical regions in schizophrenia.精神分裂症患者五个皮层下区域的体积、神经元密度和神经元总数
Brain. 2007 Mar;130(Pt 3):678-92. doi: 10.1093/brain/awl386. Epub 2007 Feb 15.
9
The organization of the thalamocortical connections of the mediodorsal thalamic nucleus in the rat, related to the ventral forebrain-prefrontal cortex topography.大鼠背内侧丘脑核的丘脑皮质连接组织,与腹侧前脑-前额叶皮质拓扑结构相关。
J Comp Neurol. 1992 Sep 8;323(2):167-97. doi: 10.1002/cne.903230204.
10
Locomotor activity induced by the non-competitive N-methyl-D-aspartate antagonist, MK-801: role of nucleus accumbens efferent pathways.非竞争性N-甲基-D-天冬氨酸拮抗剂MK-801诱导的运动活动:伏隔核传出通路的作用
Neuroscience. 2001;104(1):105-16. doi: 10.1016/s0306-4522(01)00047-1.

引用本文的文献

1
Ultra-high Field fMRI Reveals Effect of Ketamine on Vocal Processing in Common Marmosets.超高场功能磁共振成像揭示氯胺酮对普通狨猴发声处理的影响。
J Neurosci. 2025 Apr 9;45(15):e0651242025. doi: 10.1523/JNEUROSCI.0651-24.2025.
2
Glial cell deficits are a key feature of schizophrenia: implications for neuronal circuit maintenance and histological differentiation from classical neurodegeneration.神经胶质细胞缺陷是精神分裂症的一个关键特征:对神经元回路维持及与经典神经退行性变在组织学上的区分的影响。
Mol Psychiatry. 2025 Mar;30(3):1102-1116. doi: 10.1038/s41380-024-02861-6. Epub 2024 Dec 5.
3
Characterization of the extracellular free water signal in schizophrenia using multi-site diffusion MRI harmonization.
使用多部位扩散 MRI 协调对精神分裂症细胞外自由水信号的特征描述。
Mol Psychiatry. 2023 May;28(5):2030-2038. doi: 10.1038/s41380-023-02068-1. Epub 2023 Apr 24.
4
Gene Enrichment Analysis of Astrocyte Subtypes in Psychiatric Disorders and Psychotropic Medication Datasets.精神障碍和精神药物数据集中天冬氨酸能亚型的基因富集分析。
Cells. 2022 Oct 21;11(20):3315. doi: 10.3390/cells11203315.
5
Spatial-temporal topography in neurogenesis of the macaque thalamus.灵长类动物丘脑神经发生的时空拓扑结构。
Brain Struct Funct. 2022 Jun;227(5):1673-1682. doi: 10.1007/s00429-022-02463-4. Epub 2022 Feb 11.
6
A Case for Thalamic Mechanisms of Schizophrenia: Perspective From Modeling 22q11.2 Deletion Syndrome.精神分裂症的丘脑机制案例:来自 22q11.2 缺失综合征建模的视角。
Front Neural Circuits. 2021 Dec 8;15:769969. doi: 10.3389/fncir.2021.769969. eCollection 2021.
7
Astrocytes in Neuropsychiatric Disorders: A Review of Postmortem Evidence.神经精神疾病中的星形胶质细胞:尸检证据综述。
Adv Neurobiol. 2021;26:153-172. doi: 10.1007/978-3-030-77375-5_8.
8
Thalamic dopamine D2-receptor availability in schizophrenia: a study on antipsychotic-naive patients with first-episode psychosis and a meta-analysis.精神分裂症患者丘脑多巴胺 D2 受体可利用性:一项针对首发精神病且未经抗精神病药物治疗的患者的研究及荟萃分析。
Mol Psychiatry. 2022 Feb;27(2):1233-1240. doi: 10.1038/s41380-021-01349-x. Epub 2021 Nov 10.
9
A human iPSC-astroglia neurodevelopmental model reveals divergent transcriptomic patterns in schizophrenia.人类 iPSC-星形胶质细胞神经发育模型揭示精神分裂症中转录组模式的差异。
Transl Psychiatry. 2021 Oct 29;11(1):554. doi: 10.1038/s41398-021-01681-4.
10
Human iPSC-Derived Glia as a Tool for Neuropsychiatric Research and Drug Development.人诱导多能干细胞衍生的神经胶质细胞作为神经精神疾病研究和药物开发的工具
Int J Mol Sci. 2021 Sep 23;22(19):10254. doi: 10.3390/ijms221910254.