School of Biotechnology and Biomolecular Sciences, University of New South Wales, Australia.
J Infect Dis. 2012 Apr 15;205(8):1220-4. doi: 10.1093/infdis/jis178. Epub 2012 Mar 13.
Australia is experiencing a prolonged epidemic of pertussis that began in 2008. A total of 194 Bordetella pertussis isolates collected from 2008 through 2010 were typed by single-nucleotide polymorphism (SNP) analysis, by multilocus variable number tandem repeats analysis, and by fim3, prn, and ptxP sequence analyses. Strains with 2 closely related SNP profiles carrying prn2 and ptxP3 from the recently emerged SNP cluster I predominated. The data suggest increasing selection among the B. pertussis population in Australia in favor of strains carrying prn2 and ptxP3 under the pressure of acellular vaccine-induced immunity.
澳大利亚正在经历一场始于 2008 年的百日咳长期流行。通过单核苷酸多态性（SNP）分析、多位点可变数串联重复分析以及 fim3、prn 和 ptxP 序列分析，对 2008 年至 2010 年间收集的 194 株百日咳博德特氏菌分离株进行了分型。最近出现的 SNP 簇 I 中携带 prn2 和 ptxP3 的具有 2 种密切相关 SNP 谱的菌株占主导地位。这些数据表明，在无细胞疫苗诱导的免疫压力下，携带 prn2 和 ptxP3 的菌株在澳大利亚百日咳菌人群中选择增加。
