线粒体上存在两种铁受体。
Two types of receptors for iron on mitochondria.
作者信息
Weaver J, Pollack S
机构信息
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461.
出版信息
Biochem J. 1990 Oct 15;271(2):463-6. doi: 10.1042/bj2710463.
Abstract
ATP, the major ligand for Fe in the reticulocyte's low-Mr chelatable pool, transfers Fe to a mitochondrial receptor from which the Fe is incorporated into haem. However, the utilization of Fe bound to this receptor for haem synthesis is slow in comparison with that bound to a second receptor that does not accept Fe from ATP, but does accept it from AMP. The major pathway by which Fe is delivered for haem synthesis may be through hydrolysis of cytosolic ATP-Fe to AMP-Fe.
摘要
ATP是网织红细胞低分子量可螯合池中铁的主要配体，它将铁转移至线粒体受体，铁由此掺入血红素。然而，与结合到另一种受体上的铁相比，结合到该受体上的铁用于血红素合成的速率较慢。后一种受体不接受来自ATP的铁，但接受来自AMP的铁。铁被输送用于血红素合成的主要途径可能是通过胞质ATP - Fe水解为AMP - Fe 。
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