线粒体具有铁（III）受体。
Mitochondria have Fe(III) receptors.
作者信息
Weaver J, Zhan H, Pollack S
机构信息
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461.
出版信息
Biochem J. 1990 Jan 15;265(2):415-9. doi: 10.1042/bj2650415.
Abstract
Recent work has provided new evidence that ATP is the major constituent of the low-Mr iron pool in the reticulocyte. The interaction of the iron complex of ATP with mitochondria was investigated in the present experiments. When ATP-Fe3+ was incubated with mitochondria, Fe3+, free of ATP, bound with high affinity to Fe3+ receptors on the mitochondria. The binding was saturable and reversible. Iron which was complexed to PPi, nitrilotriacetate, citrate, ADP and GTP also showed saturable binding to mitochondria; Fe3+ complexed to AMP bound non-specifically, as did Fe2+/ascorbate complexed to AMP bound non-specifically, as did Fe2+/ascorbate and Fe2+/dithionite.
摘要
近期的研究工作提供了新的证据，表明ATP是网织红细胞中低分子量铁池的主要成分。在本实验中，对ATP的铁复合物与线粒体的相互作用进行了研究。当ATP-Fe3+与线粒体一起孵育时，游离于ATP的Fe3+以高亲和力与线粒体上的Fe3+受体结合。这种结合是可饱和且可逆的。与PPi、次氮基三乙酸、柠檬酸、ADP和GTP络合的铁也显示出与线粒体的可饱和结合；与AMP络合的Fe3+非特异性结合，与Fe2+/抗坏血酸和Fe2+/连二亚硫酸盐一样，与AMP络合的Fe2+/抗坏血酸也非特异性结合。
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