Cardiology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114,USA.
JACC Cardiovasc Imaging. 2012 Mar;5(3):317-28. doi: 10.1016/j.jcmg.2011.12.011.
Molecular imaging is devoted to the discovery and application of specific biological imaging approaches that complement traditional anatomical imaging. This field continues to witness impressive growth, particularly in the study of oncology, neurology, and cardiovascular disease (CVD). Interest in molecular imaging technologies stems from its great potential, not only to heighten our understanding and diagnostic capability of common CVD scenarios, but also to offer the prospect of personalized treatment and early monitoring of therapeutic response. Targeted imaging reporters are now spawning the development of combined diagnostic and therapeutic agents that can deliver therapy to individual cells in affected tissues. Recently, diagnostic imaging probes for myocardial infarction (MI), stem cell tracking, and atherosclerotic vascular disease have demonstrated significant advances in preclinical research and development (also see the Online Appendix). Clinical molecular imaging studies have further expanded into the areas of aortic dissection and aneurysm disease, and have provided new insights into aspects of heart failure and transplant medicine. In this review, we highlight outstanding CVD molecular imaging studies published over the past year. A summary of important clinical and preclinical imaging agents and applications is provided in Table 1.
分子影像学致力于发现和应用特定的生物学成像方法，以补充传统的解剖学成像。该领域继续见证着令人瞩目的增长，特别是在肿瘤学、神经病学和心血管疾病（CVD）的研究领域。人们对分子影像学技术的兴趣源于其巨大的潜力，不仅可以提高我们对常见 CVD 情况的理解和诊断能力，还可以为个性化治疗和治疗反应的早期监测提供前景。靶向成像报告器的出现正在推动联合诊断和治疗剂的发展，这些治疗剂可以将治疗递送到受影响组织中的单个细胞。最近，用于心肌梗死（MI）、干细胞跟踪和动脉粥样硬化血管疾病的诊断成像探针在临床前研究和开发方面取得了重大进展（也请参见在线附录）。临床分子影像学研究进一步扩展到主动脉夹层和动脉瘤疾病领域，并为心力衰竭和移植医学的各个方面提供了新的见解。在这篇综述中，我们重点介绍了过去一年发表的优秀 CVD 分子影像学研究。表 1 总结了重要的临床和临床前成像剂及其应用。
