分子影像学年度进展
The year in molecular imaging.
机构信息
Cardiology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
出版信息
JACC Cardiovasc Imaging. 2010 Nov;3(11):1181-95. doi: 10.1016/j.jcmg.2010.09.009.
Abstract
Molecular imaging aims to enable personalized medicine via imaging-specific molecular and cellular targets that are relevant to the diagnosis and treatment of disease. By providing in vivo readouts of biological detail, molecular imaging complements traditional anatomical imaging modalities to allow: 1) visualization of important disease-modulating molecules and cells in vivo; 2) serial investigations to image evolutionary changes in disease attributes; and 3) evaluation of the in vivo molecular effects of biotherapeutics. The added information garnered by molecular imaging can improve risk assessment and prognosticative studies, this is of particular benefit in the management of cardiovascular disease (CVD).
摘要
分子成像是通过与疾病的诊断和治疗相关的特定于分子和细胞的靶标，来实现个体化医疗的。通过提供对生物细节的体内读出，分子成像补充了传统的解剖成像方式，以允许：1）可视化体内重要的疾病调节分子和细胞；2）对疾病特征的演变进行连续研究；3）评估生物治疗药物的体内分子效应。通过分子成像获得的附加信息可以改善风险评估和预后研究，这在心血管疾病（CVD）的管理中尤其有益。
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