Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA.
Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA.
J Gen Virol. 2012 Jun;93(Pt 6):1362-1366. doi: 10.1099/vir.0.041483-0. Epub 2012 Mar 14.
Papillomaviruses (PVs) infect a wide range of vertebrates and have diversified into multiple genetic types, some of which have serious consequences for human health. Although PVs have to date only been characterized as exogenous viral forms, here we report the observation of an endogenous viral element (EPVLoa) in the genome of the platypus (Ornithorhynchus anatinus) that is related to PVs. Further data mining for endogenous PV-like elements is therefore warranted.
乳头瘤病毒 (PVs) 感染范围广泛的脊椎动物,并已多样化为多种遗传类型,其中一些对人类健康有严重后果。尽管迄今为止,PVs 仅被描述为外源性病毒形式,但在这里我们报告了在鸭嘴兽(Ornithorhynchus anatinus)基因组中观察到与 PVs 相关的内源性病毒元件 (EPVLoa)。因此,有必要进一步挖掘内源性类似 PV 的元件。