胁迫与索尔克小儿麻痹症疫苗。
Hormesis and the salk polio vaccine.
机构信息
University of Massachusetts.
出版信息
Dose Response. 2012;10(1):91-5. doi: 10.2203/dose-response.11-032.Calabrese. Epub 2011 Oct 25.
Abstract
The production of the Salk vaccine polio virus by monkey kidney cells was generated using the synthetic tissue culture medium, Mixture 199. In this paper's retrospective assessment of this process, it was discovered that Mixture 199 was modified by the addition of ethanol to optimize animal cell survival based on experimentation that revealed a hormetic-like biphasic response relationship. This hormesis-based optimization procedure was then applied to all uses of Mixture 199 and modifications of it, including its application to the Salk polio vaccine during preliminary testing and in its subsequent major societal treatment programs.
摘要
猴肾细胞生产索尔克疫苗脊髓灰质炎病毒是使用合成组织培养液 199 号进行的。在本文对这一过程的回顾性评估中，人们发现，199 号混合物是通过添加乙醇来优化动物细胞存活的，这是基于实验得出的一种类似兴奋效应的双相反应关系。这种基于兴奋效应的优化程序随后被应用于 199 号混合物及其改良物的所有用途，包括在初步测试和随后的主要社会治疗方案中用于索尔克脊髓灰质炎疫苗。
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