State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
Bioresour Technol. 2012 May;112:280-4. doi: 10.1016/j.biortech.2012.02.100. Epub 2012 Mar 3.
This paper introduces a novel process for recovery and refining of L-lactic acid from a fermentation broth. The use of a solvent extraction step, in the novel approach, has significant impacts on the following centrifugal short-path distillation conditions (operating pressure, evaporator temperature and feed flow rate). As the conditions were varied, the l-lactic acid purity and yield in the distillate were monitored. For the purpose of comparison, a series of experiments were also carried out using the existing purification process. The results showed that both of the two processes can obtain l-lactic acid with a high purity around 91.3%, while the yield obtained using the novel process reached 61.73%, which was about 20.43% higher than that using the existing process. Additionally, multiple-pass distillation observed special attention by improving the yield up to 74.63%.
本文介绍了一种从发酵液中回收和精制 L-乳酸的新工艺。在新工艺中，溶剂萃取步骤对以下离心短程蒸馏条件（操作压力、蒸发器温度和进料流量）有显著影响。随着条件的变化，监测蒸馏物中 L-乳酸的纯度和收率。为了进行比较，还使用现有纯化工艺进行了一系列实验。结果表明，两种工艺都可以得到纯度约为 91.3%的 L-乳酸，而新工艺的收率达到 61.73%，比现有工艺高出约 20.43%。此外，通过提高收率至 74.63%，多次蒸馏受到了特别关注。
