Guo Hong, Jiang Tao, Wang Jinliang, Chang Yongchao, Guo Hai, Zhang Weihong
Department of Gastroenterology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China.
J Int Med Res. 2012;40(1):204-10. doi: 10.1177/147323001204000121.
This study investigated the role of food intolerance in irritable bowel syndrome with diarrhoea (D-IBS).
Specific immunoglobulin G (IgG) antibodies against 14 common food antigens in the serum were measured in 77 patients with D-IBS and 26 healthy controls. Food-specific IgG antibodies were identified in 39 (50.65%) patients with D-IBS patients compared with four (15.38%) controls. For 12 weeks following the serological testing, 35 patients with D-IBS and food intolerance consumed diets that excluded the identified food. Changes in the main symptoms of D-IBS were evaluated before treatment and regularly during treatment in these patients.
After 4 weeks' dietary therapy, most symptoms of D-IBS had improved. By 12 weeks, all symptom scores had decreased significantly compared with the baseline scores.
The 12-week specific-food exclusion diets resulted in significant improvements in abdominal pain (bloating level and frequency), diarrhoea frequency, abdominal distension, stool shape, general feelings of distress and total symptom score compared with baseline in patients with D-IBS.
本研究调查了食物不耐受在腹泻型肠易激综合征（D-IBS）中的作用。
检测了77例D-IBS患者和26例健康对照者血清中针对14种常见食物抗原的特异性免疫球蛋白G（IgG）抗体。在D-IBS患者中，39例（50.65%）检测到食物特异性IgG抗体，而在对照者中为4例（15.38%）。血清学检测后的12周内，35例存在食物不耐受的D-IBS患者食用了排除已确定食物的饮食。对这些患者治疗前及治疗期间的D-IBS主要症状变化进行了评估。
经过4周的饮食治疗，D-IBS的大多数症状有所改善。到12周时，所有症状评分与基线评分相比均显著降低。
与基线相比，为期12周的特定食物排除饮食使D-IBS患者的腹痛（腹胀程度和频率）、腹泻频率、腹部膨胀、大便形状、总体不适感觉及总症状评分均有显著改善。
