Department of Medicine, Innlandet Hospital Trust, Kyrre Grepps gt 19, 2819, Gjøvik, Norway.
BMC Gastroenterol. 2012 Nov 21;12:166. doi: 10.1186/1471-230X-12-166.
Patients with Irritable Bowel Syndrome (IBS) often relate their symptoms to the intake of food and modify their diet. IgE-mediated food allergy is uncommon in IBS, but the role of IgG-mediated food hypersensitivity remains inconclusive. The primary aim of this study was to compare food- and yeast-specific IgG and IgG4 antibodies in subjects with and without IBS.
This was a case control study in the general population for which subjects completed questionnaires about abdominal complaints and their intake of common food items. Blood samples were collected, and food- and yeast-specific IgG and IgG4 antibodies were measured. Antibodies were measured in mg/L.
We included 269 subjects with IBS and 277 control subjects. After correction for subject characteristics and diet, there were no significant differences with regard to food- and yeast-specific IgG and IgG4 antibodies between subjects with IBS and controls. Lower values of IgG antibodies against egg (OR 0.99 (0.98 to 1.00), p = 0.002) and beef (OR 0.75 (0.60 to 0.94), p = 0.012) and higher values of IgG antibodies against chicken (OR 1.14 (1.03 to 1.27), p = 0.009) were associated with more severe symptoms.
Our findings suggest that IgG-and IgG4-mediated food and yeast hypersensitivity in IBS is unlikely. IgG antibodies against food and yeast may reflect the diet.
肠易激综合征（IBS）患者常将症状与食物摄入联系起来，并调整饮食。IgE 介导的食物过敏在 IBS 中并不常见，但 IgG 介导的食物超敏反应的作用仍不确定。本研究的主要目的是比较 IBS 患者和无 IBS 患者的食物和酵母特异性 IgG 和 IgG4 抗体。
这是一项在普通人群中进行的病例对照研究，研究对象完成了关于腹部不适和常见食物摄入的问卷。采集血样，并测量食物和酵母特异性 IgG 和 IgG4 抗体。抗体以 mg/L 表示。
我们纳入了 269 例 IBS 患者和 277 例对照患者。在校正了研究对象特征和饮食后，IBS 患者和对照组之间食物和酵母特异性 IgG 和 IgG4 抗体无显著差异。针对鸡蛋（OR 0.99（0.98 至 1.00），p=0.002）和牛肉（OR 0.75（0.60 至 0.94），p=0.012）的 IgG 抗体值较低，以及针对鸡肉（OR 1.14（1.03 至 1.27），p=0.009）的 IgG 抗体值较高与更严重的症状相关。
我们的研究结果表明，IBS 中 IgG 和 IgG4 介导的食物和酵母超敏反应不太可能发生。针对食物和酵母的 IgG 抗体可能反映了饮食。
