Mori E, Borges A S, Delfiol D J Z, Oliveira Filho J P, Gonçalves R C, Cagnini D Q, Lara M C C S H, Cunha E M S, Villalobos E M C, Nassar A F C, Castro A M M G, Brandao P E, Richtzenhain L J
Department of Preventive Veterinary Medicine and Animal Health, Faculty of Veterinary Medicine and Animal Science (FMVZ), University of São Paulo (USP), Av. Prof. Dr Orlando Marques de Paiva 87, 05508-270, Sao Paulo, SP, Brazil.
Rev Sci Tech. 2011 Dec;30(3):949-54. doi: 10.20506/rst.30.3.2090.
This report describes the first detection of an equine herpesvirus 1 (EHV-1) neuropathogenic variant (G2254/D752) in Brazil from a case of fatal equine herpesvirus myeloencephalopathy (EHM) in a mare. The results of nucleotide sequencing of the EHV-1 ORF30 gene showed that two other Brazilian EHV-1 isolates from EHM cases are representatives of the non-neuropathogenic variant (A2254/N752), suggesting that other unidentified factors are probably also involved in the neuropathogenicity of EHV-1 in horses. These findings will contribute to the epidemiological knowledge of EHV-1 infection in Brazil.
本报告描述了在巴西首次从一匹母马的致命性马疱疹病毒脑脊髓炎（EHM）病例中检测到马疱疹病毒1型（EHV-1）神经病原性变体（G2254/D752）。EHV-1 ORF30基因的核苷酸测序结果表明，另外两株来自EHM病例的巴西EHV-1分离株是非神经病原性变体（A2254/N752）的代表，这表明其他未确定的因素可能也与EHV-1在马匹中的神经病原性有关。这些发现将有助于巴西EHV-1感染的流行病学知识积累。
