Wu Hsi-Chin, Chang Chao-Hsiang, Ke Hung-Lung, Chang Wen-Shin, Cheng Hui-Ni, Lin Hui-Hui, Wu Chi-Yu, Tsai Chia-Wen, Tsai Ru-Yin, Lo Woei-Chung, Bau Da-Tian
Terry Fox Cancer Research Lab, China Medical University Hospital, Taichung, Taiwan, ROC.
Anticancer Res. 2011 Jan;31(1):221-5.
The aim of this study was to evaluate the association of polymorphic genotypes in the cyclooxygenase 2 gene (COX2), which is reported to be overexpressed in prostate tumors, with Taiwan prostate cancer patients.
Six polymorphic variants of COX2 were analyzed for their association with prostate cancer susceptibility. A total of 218 patients with prostate cancer and 436 healthy controls in central Taiwan were enrolled in this investigation. P-values and odds ratios with 95% confidence intervals were used to assess the strength of the association.
Among the six polymorphic sites examined, only the Cox-2 promoter G-765C (rs14133) genotypes were distributed differently between the prostate cancer and control groups. The COX2 -765GG genotype was associated with higher prostate cancer risk than -765GC.
These findings provide evidence that the G allele of COX2 promoter G-765C may be associated with the development of prostate cancer and may be a useful marker for early detection of prostate cancer.
本研究的目的是评估环氧化酶2基因（COX2）多态性基因型与台湾前列腺癌患者的关联，据报道该基因在前列腺肿瘤中过度表达。
分析了COX2的六个多态性变体与前列腺癌易感性的关联。本研究共招募了台湾中部的218例前列腺癌患者和436例健康对照。使用P值和95%置信区间的比值比来评估关联强度。
在所检测的六个多态性位点中，只有Cox-2启动子G-765C（rs14133）基因型在前列腺癌组和对照组之间的分布不同。COX2 -765GG基因型比-765GC基因型与更高的前列腺癌风险相关。
这些发现提供了证据，表明COX2启动子G-765C的G等位基因可能与前列腺癌的发生有关，并且可能是早期检测前列腺癌的有用标志物。
