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COX-2 基因的功能性多态性与口腔癌的风险相关。

Functional Polymorphisms in COX-2 Gene Are Correlated with the Risk of Oral Cancer.

机构信息

Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun 130041, China.

The Department of Hematology and Oncology, The Second Hospital of Jilin University, Changchun 130041, China.

出版信息

Biomed Res Int. 2015;2015:580652. doi: 10.1155/2015/580652. Epub 2015 Apr 21.

DOI:10.1155/2015/580652
PMID:25977924
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4419230/
Abstract

BACKGROUND

This meta-analysis investigated the association between functional COX-2 gene polymorphisms and the risk of oral cancer.

METHODS

Several electronic databases were searched for published studies using combinations of keywords related to COX-2 gene polymorphisms and oral cancer. After selection of relevant studies, following strict inclusion and exclusion criteria, data was performed using STATA 12.0 software.

RESULTS

We retrieved 83 studies from database search using specific search terms. After multiple rounds of selection and elimination, 7 studies were finally identified as suitable to be included in our present meta-analysis, based on their relevance and data integrity. These 7 studies contained a combined total of 2,296 oral cancer patients and 3,647 healthy controls. Our findings demonstrated that +837 T > C (rs5275) polymorphism in COX-2 showed statistically significant differences in gene frequencies in case and control groups in allele model and dominant model. Similar results were obtained with COX-2 gene polymorphism 765 G > C (rs20417). On the other hand, 1195 A > G (rs689466) polymorphism in COX-2 did not confer susceptibility to oral cancers.

CONCLUSION

Based on our results, COX-2 gene polymorphisms, +837 T > C (rs5275) and -765G > C (rs20417), showed clear links with oral cancer susceptibility, and the 1195A > G (rs689466) polymorphism did not show such a correlation.

摘要

背景

本荟萃分析研究了功能性 COX-2 基因多态性与口腔癌风险的关联。

方法

使用与 COX-2 基因多态性和口腔癌相关的关键词组合，在多个电子数据库中搜索已发表的研究。在选择相关研究后，根据严格的纳入和排除标准，使用 STATA 12.0 软件进行数据分析。

结果

我们使用特定的搜索词从数据库搜索中检索到 83 项研究。经过多轮筛选和淘汰，最终确定了 7 项研究符合我们目前荟萃分析的相关性和数据完整性标准。这 7 项研究总共包含了 2296 名口腔癌患者和 3647 名健康对照者。我们的研究结果表明，COX-2 基因的+837T>C(rs5275)多态性在等位基因模型和显性模型中，在病例组和对照组的基因频率上存在统计学显著差异。COX-2 基因 765G>C(rs20417)多态性也有类似的结果。另一方面，COX-2 基因的 1195A>G(rs689466)多态性与口腔癌易感性无关。

结论

根据我们的研究结果，COX-2 基因的+837T>C(rs5275)和-765G>C(rs20417)多态性与口腔癌易感性有明显关联，而 1195A>G(rs689466)多态性则没有相关性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f3/4419230/620bf3e19ae7/BMRI2015-580652.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f3/4419230/91361c3d847f/BMRI2015-580652.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f3/4419230/b4c42ec47cbb/BMRI2015-580652.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f3/4419230/7825f182f0fb/BMRI2015-580652.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f3/4419230/c5c93c739b5d/BMRI2015-580652.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f3/4419230/66dfcad347ab/BMRI2015-580652.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f3/4419230/620bf3e19ae7/BMRI2015-580652.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f3/4419230/91361c3d847f/BMRI2015-580652.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f3/4419230/b4c42ec47cbb/BMRI2015-580652.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f3/4419230/7825f182f0fb/BMRI2015-580652.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f3/4419230/c5c93c739b5d/BMRI2015-580652.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f3/4419230/66dfcad347ab/BMRI2015-580652.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f3/4419230/620bf3e19ae7/BMRI2015-580652.006.jpg

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