帕金森病中颞侧视网膜神经纤维的丢失：一种线粒体模式？
Loss of temporal retinal nerve fibers in Parkinson disease: a mitochondrial pattern?
机构信息
IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
出版信息
Eur J Neurol. 2013 Jan;20(1):198-201. doi: 10.1111/j.1468-1331.2012.03701.x. Epub 2012 Mar 21.
BACKGROUND AND PURPOSE
Optic nerve involvement is frequent in mitochondrial disease, and retinal abnormalities are described in Parkinson's disease (PD).
METHODS
We evaluated retinal nerve fiber layer (RNFL) thickness by optical coherence tomography in 43 patients with PD and in 86 age-matched controls. We considered separately the eyes ipsilateral and contralateral to the most affected body side in patients with PD. ancova analysis, Pearson test, and multiple regression analysis were used (P < 0.05).
RESULTS
Patients with PD showed significantly thinner temporal RNFL thickness compared to controls (P = 0.004), more evident in the eye contralateral to the most affected body side. Average RNFL thickness significantly correlated with age in both controls and patients with PD (P-values ranging from 0.001 to 0.019), whereas in patients with PD RNFL thickness did not correlate with clinical variables.
CONCLUSIONS
Our study reveals a loss of retinal nerve fibers in the temporal quadrant in PD, which is typically susceptible in mitochondrial optic neuropathies.
背景与目的
在 线粒体疾病中，视神经受累很常见，而在帕金森病（PD）中也描述了视网膜异常。
方法
我们通过光学相干断层扫描（OCT）评估了 43 名 PD 患者和 86 名年龄匹配的对照者的视网膜神经纤维层（RNFL）厚度。我们分别考虑了 PD 患者对侧和同侧最受影响身体侧的眼睛。使用了协方差分析、Pearson 检验和多元回归分析（P<0.05）。
结果
与对照组相比，PD 患者的颞侧 RNFL 厚度明显变薄（P=0.004），在最受影响身体侧的对侧眼更为明显。在对照组和 PD 患者中，平均 RNFL 厚度与年龄均显著相关（P 值范围从 0.001 到 0.019），而在 PD 患者中，RNFL 厚度与临床变量无关。
结论
我们的研究揭示了 PD 中颞象限视网膜神经纤维的丧失，这在典型的线粒体视神经病变中很常见。
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