代谢性疾病中的 microRNAs。
MicroRNAs in metabolic disease.
机构信息
Departments of Medicine and Cell Biology, Leon H. Charney Division of Cardiology and the Marc and Ruti Bell Vascular Biology and Disease Program, New York University School of Medicine, New York, NY, USA.
出版信息
Arterioscler Thromb Vasc Biol. 2013 Feb;33(2):178-85. doi: 10.1161/ATVBAHA.112.300144.
Alterations in the metabolic control of lipid and glucose homeostasis predispose an individual to develop cardiometabolic diseases, such as type 2-diabetes mellitus and atherosclerosis. Work over the last years has suggested that microRNAs (miRNAs) play an important role in regulating these physiological processes. The contribution of miRNAs in regulating metabolism is exemplified by miR-33, an intronic miRNA encoded in the Srebp genes. miR-33 controls cellular cholesterol export and fatty acid degradation, whereas its host genes stimulate cholesterol and fatty acid synthesis. Other miRNAs, such as miR-122, also play a critical role in regulating lipid homeostasis by controlling cholesterol synthesis and lipoprotein secretion in the liver. This review article summarizes the recent findings in the field, highlighting the contribution of miRNAs in regulating lipid and glucose metabolism. We will also discuss how the modulation of specific miRNAs may be a promising strategy to treat metabolic diseases.
脂质和葡萄糖稳态代谢控制的改变使个体易患心血管代谢疾病，如 2 型糖尿病和动脉粥样硬化。近年来的研究工作表明，microRNAs（miRNAs）在调节这些生理过程中起着重要作用。miR-33 就是一个例证，它是 Srebp 基因中编码的内含子 miRNA，调节细胞胆固醇输出和脂肪酸降解，而其宿主基因则刺激胆固醇和脂肪酸的合成。其他 miRNA，如 miR-122，也通过控制肝脏胆固醇合成和脂蛋白分泌在调节脂质稳态方面发挥关键作用。本文综述了该领域的最新研究进展，强调了 miRNAs 在调节脂质和葡萄糖代谢中的作用。我们还将讨论如何调节特定的 miRNAs 可能是治疗代谢性疾病的一种有前途的策略。
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