Sanli Ahmet Metin, Turkoglu Erhan, Serbes Gokhan, Sargon Mustafa Fevzi, Besalti Omer, Kilinc Kamer, Irak Alper, Sekerci Zeki
M.H. Diskapi Yildirim Beyazit Education and Research Hospital, 1st Neurosurgery Clinic, Ankara, Turkey.
Turk Neurosurg. 2012;22(2):189-95. doi: 10.5137/1019-5149.JTN.5193-11.1.
After acute spinal cord injury (SCI), a large number of axons are lost by a cascade of pathophysiological events known as a secondary injury. The main aim of the current study was to investigate the potential neuroprotective effects of curcumin on lipid peroxidation (LPO), neurological function, and ultrastructural findings after SCI.
Forty adult Wistar albino rats were randomized into five groups: control, SCI alone (50 g/cm weight drop), methylprednisolone sodium succinate (MPSS) (30 mg/kg), curcumin + dimethyl sulfoxide (DMSO) (300 mg/kg), and DMSO alone (0.1 mg/kg).
Administration of curcumin significantly decreased LPO in first 24 hours. However, there were no differences in the neurological scores of injured rats between the medication groups and the control group. Curcumin was more effective than DMSO and MPSS in reducing LPO, whereas DMSO was more effective than curcumin and MPSS in minimizing ultrastuctural changes. The results of this study indicate that curcumin exerts a beneficial effect by decreasing LPO and may reduce tissue damage.
Since ultrastructural and neurological findings does not support biochemical finding, our findings do not exclude the possibility that curcumin has a protective effect on the spinal cord ultrastructure and neurological recovery after SCI. A combination of curcumin with other vehicle may also have a considerable synergy in protecting spinal cord.
急性脊髓损伤（SCI）后，大量轴突因一系列称为继发性损伤的病理生理事件而丢失。本研究的主要目的是探讨姜黄素对SCI后脂质过氧化（LPO）、神经功能和超微结构变化的潜在神经保护作用。
40只成年Wistar白化大鼠随机分为五组：对照组、单纯SCI组（50 g/cm重物坠落）、甲泼尼龙琥珀酸钠（MPSS）组（30 mg/kg）、姜黄素+二甲基亚砜（DMSO）组（300 mg/kg）和单纯DMSO组（0.1 mg/kg）。
姜黄素给药在最初24小时内显著降低了LPO。然而，给药组与对照组之间受伤大鼠的神经评分没有差异。在降低LPO方面，姜黄素比DMSO和MPSS更有效，而在最小化超微结构变化方面，DMSO比姜黄素和MPSS更有效。本研究结果表明，姜黄素通过降低LPO发挥有益作用，并可能减少组织损伤。
由于超微结构和神经学结果不支持生化结果，我们的研究结果不排除姜黄素对SCI后脊髓超微结构和神经恢复具有保护作用的可能性。姜黄素与其他载体联合使用在保护脊髓方面也可能具有相当大的协同作用。
