Sanivarapu Raghavendra, Vallabhaneni Vijayalakshmi, Verma Vivek
Nassau University Medical Center, East Meadow, NY 11554, USA.
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Neurol Res Int. 2016;2016:9468193. doi: 10.1155/2016/9468193. Epub 2016 May 19.
Current treatment for spinal cord injury (SCI) is supportive at best; despite great efforts, the lack of better treatment solutions looms large on neurological science and medicine. Curcumin, the active ingredient in turmeric, a spice known for its medicinal and anti-inflammatory properties, has been validated to harbor immense effects for a multitude of inflammatory-based diseases. However, to date there has not been a review on curcumin's effects on SCI. Herein, we systematically review all known data on this topic and juxtapose results of curcumin with standard therapies such as corticosteroids. Because all studies that compare the two show superior results for curcumin over corticosteroids, it could be true that curcumin better acts at the inflammatory source of SCI-mediated neurological injury, although this question remains unanswered in patients. Because curcumin has shown improvements from current standards of care in other diseases with few true treatment options (e.g., osteoarthritis), there is immense potential for this compound in treating SCI. We critically and systematically summarize available data, discuss clinical implications, and propose further testing of this well-tolerated compound in both the preclinical and the clinical realms. Analyzing preclinical data from a clinical perspective, we hope to create awareness of the incredible potential that curcumin shows for SCI in a patient population that direly needs improvements on current therapy.
目前针对脊髓损伤（SCI）的治疗充其量只是支持性的；尽管付出了巨大努力，但缺乏更好的治疗方案仍是神经科学和医学面临的重大问题。姜黄素是姜黄中的活性成分，姜黄是一种以其药用和抗炎特性而闻名的香料，已被证实对多种炎症性疾病具有巨大作用。然而，迄今为止，尚未有关于姜黄素对脊髓损伤影响的综述。在此，我们系统地回顾了关于该主题的所有已知数据，并将姜黄素的结果与皮质类固醇等标准疗法的结果进行了对比。因为所有比较两者的研究都表明姜黄素的效果优于皮质类固醇，所以姜黄素可能在脊髓损伤介导的神经损伤的炎症源头发挥了更好的作用，尽管在患者中这个问题仍未得到解答。由于姜黄素在其他几乎没有真正治疗选择的疾病（如骨关节炎）中已显示出比当前护理标准有所改善，所以这种化合物在治疗脊髓损伤方面具有巨大潜力。我们批判性地、系统地总结了现有数据，讨论了临床意义，并建议在临床前和临床领域对这种耐受性良好的化合物进行进一步测试。从临床角度分析临床前数据，我们希望让人们意识到姜黄素在急需改进当前治疗方法的患者群体中对脊髓损伤所展现出的巨大潜力。
