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toll 样受体：抗病毒免疫的关键参与者。

Toll-like receptors: key players in antiviral immunity.

机构信息

Division of Immunology & Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720-3200, USA.

出版信息

Curr Opin Virol. 2011 Dec;1(6):447-54. doi: 10.1016/j.coviro.2011.10.006. Epub 2011 Oct 28.

DOI:10.1016/j.coviro.2011.10.006
PMID:22440908
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3311989/
Abstract

TLRs are a family of innate receptors whose specificities are predetermined in the germline. Therefore, TLRs have evolved to recognize conserved features of microbes. Viruses typically lack the conserved features common to other pathogen classes, so the innate immune system has evolved to recognize viral nucleic acid as a hallmark of viral infection. In this review we discuss examples of TLR-mediated viral recognition and the functional consequences of this recognition for antiviral immunity.

摘要

TLRs 是一组先天受体家族，其特异性在种系中预先确定。因此，TLRs 已经进化到能够识别微生物的保守特征。病毒通常缺乏与其他病原体类别共有的保守特征，因此先天免疫系统已经进化到能够将病毒核酸识别为病毒感染的标志。在这篇综述中，我们讨论了 TLR 介导的病毒识别的例子，以及这种识别对抗病毒免疫的功能后果。