NIHR Respiratory Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust and Imperial College, London, UK.
Respiration. 2012;84(3):193-9. doi: 10.1159/000336549. Epub 2012 Mar 22.
The chronic obstructive pulmonary disease (COPD) assessment test (CAT) is a simple, self-completion questionnaire developed to measure health status in patients with COPD, which is potentially suitable for routine clinical use.
The purpose of this study was to establish the determinants of the CAT score in routine clinical practice.
Patients attending the clinic completed the CAT score before being seen. Clinical data, including, where available, plethysmographic lung volumes, transfer factor and arterial blood gas analysis, were recorded on a pro forma in the clinic.
In 224 patients (36% female), mean forced expiratory volume in 1 s (FEV₁) was 40.1% (17.9) of predicted (%pred); CAT score was associated with exacerbation frequency [0-1/year 20.1 (7.6); 2-4/year 23.5 (7.8); >4/year 28.5 (7.3), p < 0.0001; 41/40/19% in each category] and with Medical Research Council (MRC) dyspnoea score (r² = 0.26, p < 0.0001) rising approximately 4 points with each grade. FEV(1) %pred had only a weak influence. Using stepwise regression, CAT score = 2.48 + 4.12 [MRC (1-5) dyspnoea score] + 0.08 (FEV(1) %pred) + 1.06 (exacerbation rate/year)] (r² = 0.36, p < 0.0001). The CAT score was higher in patients (n = 54) with daily sputum production [25.9 (7.5) vs. 22.2 (8.2); p = 0.004]. Detailed lung function (plethysmography and gas transfer) was available in 151 patients but had little influence on the CAT score.
The CAT score is associated with clinically important variables in patients with COPD and enables health status measurement to be performed in routine clinical practice.
慢性阻塞性肺疾病（COPD）评估测试（CAT）是一种简单的、自我完成的问卷，旨在测量 COPD 患者的健康状况，它可能适合常规临床使用。
本研究旨在确定 CAT 评分在常规临床实践中的决定因素。
患者在就诊时完成 CAT 评分。临床数据，包括肺活量计肺容积、转移因子和动脉血气分析（如有），在诊所的表格上记录。
在 224 名患者（36%为女性）中，第 1 秒用力呼气量（FEV₁）为预计值的 40.1%（17.9%）；CAT 评分与加重频率相关[0-1/年为 20.1（7.6）；2-4/年为 23.5（7.8）；>4/年为 28.5（7.3），p<0.0001]，并与英国医学研究理事会（MRC）呼吸困难评分相关（r²=0.26，p<0.0001），每增加一级，评分增加约 4 分。FEV₁%pred 仅有微弱影响。使用逐步回归，CAT 评分=2.48+4.12[MRC（1-5）呼吸困难评分]+0.08（FEV₁%pred）+1.06（加重率/年）]（r²=0.36，p<0.0001）。每日咳痰患者（n=54）的 CAT 评分较高[25.9（7.5）比 22.2（8.2）；p=0.004]。151 名患者有详细的肺功能（肺活量计和气体转移）数据，但对 CAT 评分影响不大。
CAT 评分与 COPD 患者的临床重要变量相关，能够在常规临床实践中进行健康状况测量。
